In this paper we have introduced and investigated the difference triple sequence spaces c³0(Δ³), c³(Δ³), c³R(Δ³), ????³∞(Δ³) and c³B(Δ³) applying the difference operator Δ³, on the triple sequence (xlmn) and studied some of their algebraic and topological properties. We have also proved some inclusion relation involving these sequence spaces.