Let R be a commutative ring with unity and M be a unitary R module. Let Nil(M) be the set of all nilpotent elements of M. The entire nilpotent element graph of M over R is an undirected graph E(G(M)) with vertex set as M and any two distinct vertices x and y are adjacent if and only if x + y ∈ Nil(M). In this paper we attempt to study the domination in the graph E(G(M)) and investigate the domination number as well as bondage number of E(G(M)) and its induced subgraphs N(G(M)) and Non(G(M)). Some domination parameters of E(G(M)) are also studied. It has been showed that E(G(M)) is excellent, domatically full and well covered under certain conditions.