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dc.contributoren-US
dc.creatorGhasemi, Ghasem
dc.creatorMohamadzade, Reihaneh
dc.date2019-01-09
dc.date.accessioned2019-09-10T17:53:39Z
dc.date.available2019-09-10T17:53:39Z
dc.identifierhttp://www.jcchems.com/index.php/JCCHEMS/article/view/911
dc.identifier.urihttps://revistaschilenas.uchile.cl/handle/2250/108738
dc.descriptionIn this work quantitative structure-activity relationship (QSAR) study has been done on 1,2-ethylenediamine derivatives as anti-tuberculosis drugs. Genetic algorithm (GA), artificial neural network (ANN), multiple linear regressions (stepwise-MLR) and Imperialist Competitive Algorithm (ICA), were used to create the nonlinear and linear QSAR models. The root-mean square errors of the training set and the test set for GA–ANN models using the jack-knife method, were 0.1402, 0.1304 and Q2 = 0.94. Also, the R and R2 values 0.85, 0.73 in the gas phase were obtained from a GA-stepwise-MLR model. Q2 of training set for PLS was 0.52. The results obtained from this work indicate that ANN and ICA models are more effective than other statistical methods and exhibit reasonable prediction capabilities. The best descriptors are G3u, HATS2e, F02(C-N), GGI10, RDF040m, Mor22p, Mor05p, TIC4, H4e, H-052, G2m and G1e.en-US
dc.formatapplication/pdf
dc.languageeng
dc.publisherSociedad Chilena de Químicaen-US
dc.relationhttp://www.jcchems.com/index.php/JCCHEMS/article/view/911/272
dc.rightsCopyright (c) 2019 Journal of the Chilean Chemical Societyen-US
dc.rightshttp://creativecommons.org/licenses/by-nc-sa/4.0en-US
dc.sourceJournal of the Chilean Chemical Society; Vol 63, No 4 (2018): Journal of the Chilean Chemical Societyen-US
dc.source0717-9707
dc.subjectTuberculosis; quantitative structure-activity relationship; 1,2-ethylenediamine derivatives; Genetic Algorithm and Imperialist Competitive Algorithm; Artificial Neural Networken-US
dc.titleA 2D/3D-QSAR STUDY ON BIOLOGICAL ACTIVITIES OF 1,2-ETHYLENDIAMINE DERIVATIVES AS ANTI-TUBERCULOSIS DRUGSen-US
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.typeen-US


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