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ALCOHOL CONSUMPTION PATTERNS AND GENOTYPES DETERMINING ALCOHOL TOLERANCE IN CHILEAN UNIVERSITY STUDENTS

Patrones de consumo y genotipos determinantes de la tolerancia al alcohol: estudio en estudiantes universitarios de Santiago de Chile.

dc.contributoren-US
dc.contributores-ES
dc.creatorSilva, Constanza P; Universidad de Chile
dc.creatorFlores, Sergio V; Universidad de Chile
dc.date2015-06-01
dc.date.accessioned2019-11-11T18:26:20Z
dc.date.available2019-11-11T18:26:20Z
dc.identifierhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/view/4018
dc.identifier.urihttps://revistaschilenas.uchile.cl/handle/2250/110642
dc.descriptionBackground: Alleles involved in inefficient (ADH1B2*2 and ALDH2*2) or efficient (SNP6, ADH4 gene) alcohol metabolism may influence the risk of alcoholism. Alcoholism susceptibility has been classified as protector and risk-dependence phenotypes, associated with inefficient and efficient alcohol genetic metabolizing variants, respectively. Aim: To investigate the possible association between genetic protective and risk-dependence variants and alcohol intake patterns. Material and methods: Saliva DNA samples were obtained and the AUDIT (Alcohol Use Disorders Identification Test) questionnaire was applied to 210 university students aged between 18 and 25 years old. Results: No statistically significant association between protective or risk-dependence genetic variants and alcohol pattern intake was detected. However, new categories of alcohol intake patterns -not included in the AUDIT questionnaire- were identified. Conclusions: No association between the protector and risk-dependence phenotypes and patterns of alcohol consumption was detected in this sample of students.en-US
dc.descriptionBackground: Alleles involved in inefficient (ADH1B2*2 and ALDH2*2) or efficient (SNP6, ADH4 gene) alcohol metabolism may influence the risk of alcoholism. Alcoholism susceptibility has been classified as protector and risk-dependence phenotypes, associated with inefficient and efficient alcohol genetic metabolizing variants, respectively. Aim: To investigate the possible association between genetic protective and risk-dependence variants and alcohol intake patterns. Material and methods: Saliva DNA samples were obtained and the AUDIT (Alcohol Use Disorders Identification Test) questionnaire was applied to 210 university students aged between 18 and 25 years old. Results: No statistically significant association between protective or risk-dependence genetic variants and alcohol pattern intake was detected. However, new categories of alcohol intake patterns -not included in the AUDIT questionnaire- were identified. Conclusions: No association between the protector and risk-dependence phenotypes and patterns of alcohol consumption was detected in this sample of students.es-ES
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dc.languagespa
dc.publisherRevista Médica de Chilees-ES
dc.relationhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/view/4018/1217
dc.relationhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/downloadSuppFile/4018/16855
dc.relationhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/downloadSuppFile/4018/16933
dc.relationhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/downloadSuppFile/4018/16934
dc.relationhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/downloadSuppFile/4018/17015
dc.relationhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/downloadSuppFile/4018/17016
dc.relationhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/downloadSuppFile/4018/17017
dc.relationhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/downloadSuppFile/4018/17018
dc.relationhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/downloadSuppFile/4018/17427
dc.relationhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/downloadSuppFile/4018/19409
dc.sourceRevista Médica de Chile; Vol. 143, núm. 6 (2015): JUNIO 2015es-ES
dc.source0034-9887
dc.subjectAlcohol Dehydrogenase; Alcohol Drinking; Aldehyde Dehydrogenase; Genetics, Population; Genetic Variationen-US
dc.subjectAlcohol Dehydrogenase; Alcohol Drinking; Aldehyde Dehydrogenase; Genetics, Population; Genetic Variationes-ES
dc.titleALCOHOL CONSUMPTION PATTERNS AND GENOTYPES DETERMINING ALCOHOL TOLERANCE IN CHILEAN UNIVERSITY STUDENTSen-US
dc.titlePatrones de consumo y genotipos determinantes de la tolerancia al alcohol: estudio en estudiantes universitarios de Santiago de Chile.es-ES
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.typees-ES


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