Pubarquia precoz: Experiencia en 173 casos

Author
Eyzaguirre, Francisca; Instituto de Investigaciones Materno Infantil, Facultad de Medicina, Universidad de Chile.

Bancalari, Rodrigo; Departamento de Pediatría, Facultad de Medicina, Universidad de Los Andes, Chile.

Youlton, Ronald; Departamento de Pediatría, Unidad de Endocrinología, Clínica Las Condes

Román, Rossana; Instituto de Investigaciones Materno Infantil, Facultad de Medicina, Universidad de Chile.|Departamento de Pediatría, Unidad de Endocrinología, Clínica Santa María, Chile.

Silva, Ricardo; Departamento de Pediatría, Unidad de Endocrinología, Clínica Santa María, Chile.

García, Hernán; Departamento de Pediatría, Unidad de Endocrinología, Clínica Santa María, Chile.|Departamento de Pediatría, Unidad de Endocrinología, Pontificia Universidad Católica de Chile

Mericq, Verónica; Instituto de Investigaciones Materno Infantil, Facultad de Medicina, Universidad de Chile.|Departamento de Pediatría, Unidad de Endocrinología, Clínica Las Condes

Full text
http://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/view/213
Abstract
Background: Precocious pubarche (PP), defined as the developmentof sexual pubic hair before 8 years of age in females and before 9 years in males, is usually a benigncondition but it can also be the first sign of an underlying disease. Aim: To analyze the etiology andperform a short term follow up in a cohort of patients with PP. Material and methods: A group of173 patients (158 females) consulted for PP with a mean age of 7.4±0.1 years. These patients werefollowed between 15 to 60 months. Anthropometric measurements, bone age, serum levels of totaltestosterone, 17 OH progesterone (17 OHP) and dehydroepiandrosterone sulphate (DHEAS) wereevaluated. Results: Mean birth weight and length was 3024.1±50.5 g and 48.5±0.3 cm,respectively. Ten percent of children were small for gestational age at birth. Bone age wasaccelerated by 1.1±0.01 years. One hundred and twelve patients were classified as having idiopathicPP (64.7%; 105 females), 29 as central precocious puberty (16.8%; only females), 16 as exaggeratedadrenarche (EA 9.2%; 13 females) and 16 as non classical adrenal hyperplasia (9.2%; 11 females).Conclusions: PP represents a common and usually benign sign. However, 26% of cases had apathologic underlying condition. Therefore, all children with PP should be evaluated by a pediatricendocrinologist. Low birth weight was not frequent in this cohort and these patients did not show EA
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