PORPHYRIA CUTANEA TARDA. CASE REPORT
Porfiria cutánea tarda. Caso Clínico
dc.contributor | en-US | |
dc.contributor | es-ES | |
dc.creator | Hermosilla B, Nicolás | |
dc.creator | De Toro, Gonzalo; Servicio de Anatomía Patológica, Hospital Puerto Montt | |
dc.creator | Molgó, Montserrat | |
dc.date | 2018-08-20 | |
dc.date.accessioned | 2019-11-11T18:26:21Z | |
dc.date.available | 2019-11-11T18:26:21Z | |
dc.identifier | http://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/view/6492 | |
dc.identifier.uri | https://revistaschilenas.uchile.cl/handle/2250/110665 | |
dc.description | Porphyria cutanea tarda (PCT) is the most common type of porphyria: it is characterized by blistering lesions, erosions and crusts on the back of the hands, associated with photosensitivity and facial hypertrichosis. It is produced by acquired or hereditary deficiency of the enzyme UROD, fifth enzyme in the chain of production of the Heme group. This causes accumulation of porphyrins in the liver, which are subsequently mobilized to the skin, where lesions are generated by photosensitivity. This deficiency can be exacerbated by multiple causes. We report a 51 year old female presenting with the characteristic dermal lesions described above, which disappeared when she discontinued her hormone replacement therapy with estradiol and dydrogesterone. Urinary and blood uroporphyrin and hexacarboxyl porphyrins were elevated and plasma ferritin was 479 ng/ml. Hormone replacement therapy was discontinued and phlebotomies were attempted but not tolerated by the patient. The dermic lesions have not relapsed. | en-US |
dc.description | Porphyria cutanea tarda (PCT) is the most common type of porphyria: it is characterized by blistering lesions, erosions and crusts on the back of the hands, associated with photosensitivity and facial hypertrichosis. It is produced by acquired or hereditary deficiency of the enzyme UROD, fifth enzyme in the chain of production of the Heme group. This causes accumulation of porphyrins in the liver, which are subsequently mobilized to the skin, where lesions are generated by photosensitivity. This deficiency can be exacerbated by multiple causes. We report a 51 year old female presenting with the characteristic dermal lesions described above, which disappeared when she discontinued her hormone replacement therapy with estradiol and dydrogesterone. Urinary and blood uroporphyrin and hexacarboxyl porphyrins were elevated and plasma ferritin was 479 ng/ml. Hormone replacement therapy was discontinued and phlebotomies were attempted but not tolerated by the patient. The dermic lesions have not relapsed. | es-ES |
dc.format | application/pdf | |
dc.language | spa | |
dc.publisher | Revista Médica de Chile | es-ES |
dc.relation | http://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/view/6492/4235 | |
dc.relation | http://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/downloadSuppFile/6492/32939 | |
dc.relation | http://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/downloadSuppFile/6492/32940 | |
dc.relation | http://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/downloadSuppFile/6492/32941 | |
dc.relation | http://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/downloadSuppFile/6492/32942 | |
dc.relation | http://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/downloadSuppFile/6492/32943 | |
dc.relation | http://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/downloadSuppFile/6492/32944 | |
dc.relation | http://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/downloadSuppFile/6492/32945 | |
dc.relation | http://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/downloadSuppFile/6492/32946 | |
dc.relation | http://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/downloadSuppFile/6492/32947 | |
dc.relation | http://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/downloadSuppFile/6492/33390 | |
dc.relation | http://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/downloadSuppFile/6492/34843 | |
dc.relation | http://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/downloadSuppFile/6492/35991 | |
dc.source | Revista Médica de Chile; Vol. 146, núm. 8 (2018): AGOSTO 2018 | es-ES |
dc.source | 0034-9887 | |
dc.subject | Estrogens; Porphyrias; Porphyria Cutanea Tarda | en-US |
dc.subject | Estrogens; Porphyrias; Porphyria Cutanea Tarda | es-ES |
dc.title | PORPHYRIA CUTANEA TARDA. CASE REPORT | en-US |
dc.title | Porfiria cutánea tarda. Caso Clínico | es-ES |
dc.type | info:eu-repo/semantics/article | |
dc.type | info:eu-repo/semantics/publishedVersion | |
dc.type | es-ES |