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Porfiria cutánea tarda. Caso Clínico

dc.contributoren-US
dc.contributores-ES
dc.creatorHermosilla B, Nicolás
dc.creatorDe Toro, Gonzalo; Servicio de Anatomía Patológica, Hospital Puerto Montt
dc.creatorMolgó, Montserrat
dc.date2018-08-20
dc.date.accessioned2019-11-11T18:26:21Z
dc.date.available2019-11-11T18:26:21Z
dc.identifierhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/view/6492
dc.identifier.urihttps://revistaschilenas.uchile.cl/handle/2250/110665
dc.descriptionPorphyria cutanea tarda (PCT) is the most common type of porphyria: it is characterized by blistering lesions, erosions and crusts on the back of the hands, associated with photosensitivity and facial hypertrichosis. It is produced by acquired or hereditary deficiency of the enzyme UROD, fifth enzyme in the chain of production of the Heme group. This causes accumulation of porphyrins in the liver, which are subsequently mobilized to the skin, where lesions are generated by photosensitivity. This deficiency can be exacerbated by multiple causes. We report a 51 year old female presenting with the characteristic dermal lesions described above, which disappeared when she discontinued her hormone replacement therapy with estradiol and dydrogesterone. Urinary and blood uroporphyrin and hexacarboxyl porphyrins were elevated and plasma ferritin was 479 ng/ml. Hormone replacement therapy was discontinued and phlebotomies were attempted but not tolerated by the patient. The dermic lesions have not relapsed.en-US
dc.descriptionPorphyria cutanea tarda (PCT) is the most common type of porphyria: it is characterized by blistering lesions, erosions and crusts on the back of the hands, associated with photosensitivity and facial hypertrichosis. It is produced by acquired or hereditary deficiency of the enzyme UROD, fifth enzyme in the chain of production of the Heme group. This causes accumulation of porphyrins in the liver, which are subsequently mobilized to the skin, where lesions are generated by photosensitivity. This deficiency can be exacerbated by multiple causes. We report a 51 year old female presenting with the characteristic dermal lesions described above, which disappeared when she discontinued her hormone replacement therapy with estradiol and dydrogesterone. Urinary and blood uroporphyrin and hexacarboxyl porphyrins were elevated and plasma ferritin was 479 ng/ml. Hormone replacement therapy was discontinued and phlebotomies were attempted but not tolerated by the patient. The dermic lesions have not relapsed.es-ES
dc.formatapplication/pdf
dc.languagespa
dc.publisherRevista Médica de Chilees-ES
dc.relationhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/view/6492/4235
dc.relationhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/downloadSuppFile/6492/32939
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dc.relationhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/downloadSuppFile/6492/35991
dc.sourceRevista Médica de Chile; Vol. 146, núm. 8 (2018): AGOSTO 2018es-ES
dc.source0034-9887
dc.subjectEstrogens; Porphyrias; Porphyria Cutanea Tardaen-US
dc.subjectEstrogens; Porphyrias; Porphyria Cutanea Tardaes-ES
dc.titlePORPHYRIA CUTANEA TARDA. CASE REPORTen-US
dc.titlePorfiria cutánea tarda. Caso Clínicoes-ES
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.typees-ES


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