The first issue of Revista Médica de Chile appeared in July, 1872. Since then it has been published monthly and thus it became one of the oldest medical journals being printed since the 19th Century. The opening Editorial in the first issue, labeled as “Prospecto”and written by the first editor, Germán Schneider, M.D., is reproduced. The current Editors comment the main statements found in that document establishing the purpose and scope of this journal. There are good reasons to sustain that through its 140 years of life, Revista Médica de Chile has fully accomplished the expectations of its founders and the owning institution: Sociedad Médica de Santiago-Chilean Society of Internal Medicine. The journal is serving well the medical community as a forum to present and discuss clinical experience, topics in scientific and technological advances related to medicine, medical education, medical ethics, and public health.