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CARDIAC ADVERSE EFFECTS OF DOMPERIDONE IN ADULT PATIENTS: A SYSTEMATIC REVIEW

Efectos adversos cardíacos de la domperidona en pacientes adultos: revisión sistemática.

dc.contributoren-US
dc.contributores-ES
dc.creatorMarzi, Marta
dc.creatorWeitz, Darío; 1Departamento de Matemática y Estadística, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario. Rosario, Argentina
dc.creatorÁvila, Aylén; 1Departamento de Matemática y Estadística, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario. Rosario, Argentina
dc.creatorMolina, Gabriel; Departamento de Matemática y Estadística, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario. Rosario, Argentina.
dc.creatorCaraballo, Lucía; 1Departamento de Matemática y Estadística, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario. Rosario, Argentina.
dc.creatorPiskulic, Laura; Departamento de Matemática y Estadística, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario. Rosario, Argentina.
dc.date2014-12-15
dc.date.accessioned2019-11-11T18:26:33Z
dc.date.available2019-11-11T18:26:33Z
dc.identifierhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/view/3594
dc.identifier.urihttps://revistaschilenas.uchile.cl/handle/2250/110721
dc.descriptionBackground: Domperidone is widely prescribed in patients with gastrointestinal disorders but some cardiac adverse effects have been recently reported. Aim: To evaluate the risk of QT prolongation, ventricular arrhythmias and sudden cardiac death associated with the use of oral domperidone in adults without cancer. Material and methods: Systematic searches in MEDLINE, LILACS, ScIELO, the Cochrane Library and regulatory agencies websites were performed, followed by a manual search of cited references. The search strategy consisted of combining free and indexed text words without any date or language restriction. Results: Three case-control studies met the inclusion criteria; none of them evaluated QT interval prolongation. With low risk of bias, each study quantified the risk of ventricular arrhythmia or sudden cardiac death (VA/SCD). The odds ratios for these events in these studies were 4.7 (95% confidence interval (CI): 1.4-16), 1.59 (95% CI: 1.28-1.98) and 11.02 (95% CI: 2.02-62.3) respectively. A significantly increased risk was observed in patients older than 60 years of age or receiving doses > 30 mg/day. Conclusions: Heterogeneity between selected studies did not allow the computation of a summary measure. However, evidence was found that an increased risk of VA/SCD is associated with the use of oral domperidone in adults.en-US
dc.descriptionCARDIAC ADVERSE EFFECTS OF DOMPERIDONE IN ADULT PATIENTS: A SYSTEMATIC REVIEW Background: Domperidone is widely prescribed in patients with gastrointestinal disorders but some cardiac adverse effects have been recently reported. Aim: To evaluate the risk of QT prolongation, ventricular arrhythmias and sudden cardiac death associated with the use of oral domperidone in adults without cancer. Material and methods: Systematic searches in MEDLINE, LILACS, ScIELO, the Cochrane Library and regulatory agencies websites were performed, followed by a manual search of cited references. The search strategy consisted of combining free and indexed text words without any date or language restriction. Results: Three case-control studies met the inclusion criteria; none of them evaluated QT interval prolongation. With low risk of bias, each study quantified the risk of ventricular arrhythmia or sudden cardiac death (VA/SCD). The odds ratios for these events in these studies were 4.7 (95% confidence interval (CI): 1.4-16), 1.59 (95% CI: 1.28-1.98) and 11.02 (95% CI: 2.02-62.3) respectively. A significantly increased risk was observed in patients older than 60 years of age or receiving doses > 30 mg/day. Conclusions: Heterogeneity between selected studies did not allow the computation of a summary measure. However, evidence was found that an increased risk of VA/SCD is associated with the use of oral domperidone in adults.es-ES
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dc.publisherRevista Médica de Chilees-ES
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dc.sourceRevista Médica de Chile; Vol. 143, núm. 1 (2015): ENERO 2015es-ES
dc.source0034-9887
dc.subjectArrhythmias, cardiac; Domperidone; Jervell-Lange Nielsen syndrome; Reviewen-US
dc.subjectArrhythmias, cardiac; Domperidone; Jervell-Lange Nielsen syndrome; Reviewes-ES
dc.titleCARDIAC ADVERSE EFFECTS OF DOMPERIDONE IN ADULT PATIENTS: A SYSTEMATIC REVIEWen-US
dc.titleEfectos adversos cardíacos de la domperidona en pacientes adultos: revisión sistemática.es-ES
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.typees-ES


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