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Regional distribution of adipose tissue in correlation with endometrial cancer

Regional distribution of adipose tissue in correlation with endometrial cancer

dc.contributorThe European Social Fund, Human Resources Development Operational Programme 2007-2013, project no.7135/5/30.04.2014 POSDRU.en-US
dc.contributores-ES
dc.creatorCiortea, Razvan
dc.creatorMalutan, Andrei M
dc.creatorAngheluta, Lenuta M
dc.creatorBucuri, Carmen El
dc.creatorRada, Maria P
dc.creatorMihu, Dan
dc.date2016-12-27
dc.date.accessioned2019-11-11T18:26:33Z
dc.date.available2019-11-11T18:26:33Z
dc.identifierhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/view/5137
dc.identifier.urihttps://revistaschilenas.uchile.cl/handle/2250/110726
dc.descriptionGRP78 LEVELS, REGIONAL FAT DISTRIBUTION AND ENDOMETRIAL CANCER Background: The association of obesity with endometrial cancer is supported by the presence of endoplasmic reticulum (ER) stress in the adipocyte. Glucose-regulated protein 78 (GRP78) is a marker for ER stress. This protein is a central regulator of ER stress due to its major anti-apoptotic role. It plays an important role in tumor development, progression and chemoresistance. Aim: To look for an association between android and gynoid obesity, plasma GRP78 levels and endometrial cancer. Material and methods: Forty four patients with endometrial cancer aged 72 ± 6 years and 44 healthy women aged 55 ± 9 years were studied. Android and gynoid fat distribution were determined by dual X-ray absorptiometry and plasma GRP78 levels were measured. Results: GRP78 plasma levels were significantly higher in patients with endometrial cancer as compared to the control group. Android fat distribution had a positive correlation with plasma GRP78 levels (pen-US
dc.descriptionBackground: The association of obesity with endometrial cancer is supported by the presence of endoplasmic reticulum (ER) stress in the adipocyte. Glucose-regulated protein 78 (GRP78) is a marker for ER stress. This protein is a central regulator of ER stress due to its major anti-apoptotic role. It plays an important role in tumor development, progression and chemoresistance. Aim: To look for an association between android and gynoid obesity, plasma GRP78 levels and endometrial cancer. Material and methods: Forty four patients with endometrial cancer aged 72 ± 6 years and 44 healthy women aged 55 ± 9 years were studied. Android and gynoid fat distribution were determined by dual X-ray absorptiometry and plasma GRP78 levels were measured. Results: GRP78 plasma levels were significantly higher in patients with endometrial cancer as compared to the control group. Android fat distribution had a positive correlation with plasma GRP78 levels (pes-ES
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dc.languageeng
dc.publisherRevista Médica de Chilees-ES
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dc.sourceRevista Médica de Chile; Vol. 144, núm. 12 (2016): DICIEMBRE 2016es-ES
dc.source0034-9887
dc.subjectAdipose Tissue; Endometrial Neoplasms; Obesityen-US
dc.subjectAdipose Tissue; Endometrial Neoplasms; Obesityes-ES
dc.titleRegional distribution of adipose tissue in correlation with endometrial canceren-US
dc.titleRegional distribution of adipose tissue in correlation with endometrial canceres-ES
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.typees-ES


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