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AMERINDIAN ADMIXTURE ESTIMATION BASED ON SEROLOGICAL AND MOLECULAR METHODS

Estimadores de mezcla amerindia basado sen métodos serológicos y moleculares.

dc.contributoren-US
dc.contributores-ES
dc.creatorPulgar-Alarcón, Iván
dc.creatorFuentes-Guajardo, Macarena; Universidad de Tarapacá
dc.creatorLlop, Elena; Universidad de Chile
dc.creatorRothhammer, Francisco; Universidad de Tarapacá Universidad de Chile
dc.date2015-03-26
dc.date.accessioned2019-11-11T18:26:45Z
dc.date.available2019-11-11T18:26:45Z
dc.identifierhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/view/3853
dc.identifier.urihttps://revistaschilenas.uchile.cl/handle/2250/110805
dc.descriptionBackground: Amerindian admixture is an important parameter to consider in epidemiological studies in American countries, to make a proper selection of cases and controls. Aim: To compare Amerindian admixture estimates obtained using ABO*A and ABO*O blood group alleles and ancestral identity markers (AIMs) in the mixed Chilean population. Subjects and Methods: Amerindian admixture rates were determined in 720 Chilean volunteers residing in Arica and born in the 15 regions of the country, using ABO*O and ABO*A alleles and 40 AIMs selected from more than 500,000 single nucleotide polymorphisms (SNP´s). Results: Mean admixture estimates obtained using ABO*O and ABO*A alleles and AIM's were 35, 47% and 48% respectively. There was concordance in estimates, with the exception of the admixture based on ABO*O allele and AIMs. Conclusions: In Chile, Amerindian admixture estimates obtained using ABO*A could be used as an alternative to AIMs in justified cases provided the sample size is reasonably large.en-US
dc.descriptionBackground: Amerindian admixture is an important parameter to consider in epidemiological studies in American countries, to make a proper selection of cases and controls. Aim: To compare Amerindian admixture estimates obtained using ABO*A and ABO*O blood group alleles and ancestral identity markers (AIMs) in the mixed Chilean population. Subjects and Methods: Amerindian admixture rates were determined in 720 Chilean volunteers residing in Arica and born in the 15 regions of the country, using ABO*O and ABO*A alleles and 40 AIMs selected from more than 500,000 single nucleotide polymorphisms (SNP´s). Results: Mean admixture estimates obtained using ABO*O and ABO*A alleles and AIM's were 35, 47% and 48% respectively. There was concordance in estimates, with the exception of the admixture based on ABO*O allele and AIMs. Conclusions: In Chile, Amerindian admixture estimates obtained using ABO*A could be used as an alternative to AIMs in justified cases provided the sample size is reasonably large.es-ES
dc.formatapplication/pdf
dc.languagespa
dc.publisherRevista Médica de Chilees-ES
dc.relationhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/view/3853/1028
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dc.relationhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/downloadSuppFile/3853/17663
dc.sourceRevista Médica de Chile; Vol. 143, núm. 4 (2015): ABRIL 2015es-ES
dc.source0034-9887
dc.subjectAmerican Native; Continental Ancestry Group; Chile, ABO Blood-Group System; Indians, South Americanen-US
dc.subjectAmerican Native; Continental Ancestry Group; Chile, ABO Blood-Group System; Indians, South Americanes-ES
dc.titleAMERINDIAN ADMIXTURE ESTIMATION BASED ON SEROLOGICAL AND MOLECULAR METHODSen-US
dc.titleEstimadores de mezcla amerindia basado sen métodos serológicos y moleculares.es-ES
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.typees-ES


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