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SPONTANEOUS REMISSION OF ACROMEGALY AND CUSHING´S DISEASE IN OLDER PATIENTS. REPORT OF TWO CASES

Remisión espontánea de acromegalia y enfermedad de Cushing en adultos mayores. Casos clínicos.

dc.contributoren-US
dc.contributores-ES
dc.creatorAraya, A Verónica; hospital clinico universidad de chile y clinica la s condes
dc.creatorEugenin, Daniela; Hospital Clinico Universidad de Chile
dc.creatorLemp, Melchor; Hospital Clinico Universidad de Chile y Clínica Las Condes
dc.date2018-07-09
dc.date.accessioned2019-11-11T18:26:47Z
dc.date.available2019-11-11T18:26:47Z
dc.identifierhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/view/6578
dc.identifier.urihttps://revistaschilenas.uchile.cl/handle/2250/110829
dc.descriptionPituitary diseases such as acromegaly and Cushing's disease require surgical or medical therapy. In some functioning pituitary tumors, a spontaneous remission of hormonal hypersecretion is observed, mainly associated to apoplexy or pituitary infarction. We report the evolution of two female patients older than 70 years at the time of diagnosis, with multiple comorbidities. In case 1, acromegaly was diagnosed at 74 years old. Sellar CT scan showed a 10-mm adenoma. During her follow-up, IGF1 levels remained normal. Nine years later, a magnetic resonance (MR) showed a 7-mm adenoma. In case 2, clinical and biochemical diagnosis of Cushing's disease was done at 71 years old. Sellar MR showed a 6-mm adenoma. Three years later, urinary cortisol normalized with no changes in adenoma at MR. Seven years later, she remains without clinical or biochemical signs of hypercortisolism. In both cases, no signs of hemorrhage were observed at MR.en-US
dc.descriptionPituitary diseases such as acromegaly and Cushing's disease require surgical or medical therapy. In some functioning pituitary tumors, a spontaneous remission of hormonal hypersecretion is observed, mainly associated to apoplexy or pituitary infarction. We report the evolution of two female patients older than 70 years at the time of diagnosis, with multiple comorbidities. In case 1, acromegaly was diagnosed at 74 years old. Sellar CT scan showed a 10-mm adenoma. During her follow-up, IGF1 levels remained normal. Nine years later, a magnetic resonance (MR) showed a 7-mm adenoma. In case 2, clinical and biochemical diagnosis of Cushing's disease was done at 71 years old. Sellar MR showed a 6-mm adenoma. Three years later, urinary cortisol normalized with no changes in adenoma at MR. Seven years later, she remains without clinical or biochemical signs of hypercortisolism. In both cases, no signs of hemorrhage were observed at MR.es-ES
dc.formatapplication/pdf
dc.languagespa
dc.publisherRevista Médica de Chilees-ES
dc.relationhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/view/6578/4176
dc.relationhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/downloadSuppFile/6578/33550
dc.relationhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/downloadSuppFile/6578/33551
dc.relationhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/downloadSuppFile/6578/33552
dc.relationhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/downloadSuppFile/6578/33553
dc.relationhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/downloadSuppFile/6578/33554
dc.relationhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/downloadSuppFile/6578/33904
dc.relationhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/downloadSuppFile/6578/35644
dc.relationhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/downloadSuppFile/6578/35645
dc.relationhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/downloadSuppFile/6578/35646
dc.sourceRevista Médica de Chile; Vol. 146, núm. 7 (2018): JULIO 2018es-ES
dc.source0034-9887
dc.subjectAcromegaly; Cellular Senescence; Pituitary ACTH Hypersecretion; Remission, Spontaneousen-US
dc.subjectAcromegaly; Cellular Senescence; Pituitary ACTH Hypersecretion; Remission, Spontaneouses-ES
dc.titleSPONTANEOUS REMISSION OF ACROMEGALY AND CUSHING´S DISEASE IN OLDER PATIENTS. REPORT OF TWO CASESen-US
dc.titleRemisión espontánea de acromegalia y enfermedad de Cushing en adultos mayores. Casos clínicos.es-ES
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.typees-ES


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