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MICRORNAS: CIRCULATING BIOMARKERS IN TYPE 2 DIABETES MELLITUS AND PHYSICAL EXERCISE

MicroRNAs: marcadores séricos en Diabetes Mellitus tipo 2 y ejercicio físico

dc.contributoren-US
dc.contributores-ES
dc.creatorGómez-Banoy, Nicolás; Universidad Nacional de Colombia
dc.creatorMockus, Ismena; Universidad Nacional de Colombia
dc.date2016-03-02
dc.date.accessioned2019-11-11T18:26:50Z
dc.date.available2019-11-11T18:26:50Z
dc.identifierhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/view/4467
dc.identifier.urihttps://revistaschilenas.uchile.cl/handle/2250/110874
dc.descriptionMicroRNAs are small, non-coding molecules with a crucial function in the cell´s biologic regulation. Circulating levels of miRNAs may be useful biomarkers in metabolic diseases such as type 2 Diabetes Mellitus (DM2), which alters the circulating concentrations of several types of miRNA. Specific serum profiles of these molecules have been identified in high-risk patients before the development of DM2 and its chronic complications. Most importantly, these profiles can be modified with physical exercise, which is crucial in the treatment of metabolic diseases. Acute physical activity alone can induce changes in tissue specific miRNAs, and responses are different in aerobic or non-aerobic training. Muscle and cardiovascular miRNAs, which may play an important role in the adaptation to exercise, are predominantly altered. Even further, there is a correlation between serum levels of miRNAs and fitness, suggesting a role for chronic exercise in their regulation. Thus, miRNAs are molecules of growing importance in exercise physiology, and may be involved in the mechanisms behind the beneficial effects of physical activity for patients with metabolic diseases.en-US
dc.descriptionMicroRNAs are small, non-coding molecules with a crucial function in the cell´s biologic regulation. Circulating levels of miRNAs may be useful biomarkers in metabolic diseases such as type 2 Diabetes Mellitus (DM2), which alters the circulating concentrations of several types of miRNA. Specific serum profiles of these molecules have been identified in high-risk patients before the development of DM2 and its chronic complications. Most importantly, these profiles can be modified with physical exercise, which is crucial in the treatment of metabolic diseases. Acute physical activity alone can induce changes in tissue specific miRNAs, and responses are different in aerobic or non-aerobic training. Muscle and cardiovascular miRNAs, which may play an important role in the adaptation to exercise, are predominantly altered. Even further, there is a correlation between serum levels of miRNAs and fitness, suggesting a role for chronic exercise in their regulation. Thus, miRNAs are molecules of growing importance in exercise physiology, and may be involved in the mechanisms behind the beneficial effects of physical activity for patients with metabolic diseases.es-ES
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dc.languagespa
dc.publisherRevista Médica de Chilees-ES
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dc.sourceRevista Médica de Chile; Vol. 144, núm. 3 (2016): MARZO 2016es-ES
dc.source0034-9887
dc.subjectDiabetes Mellitus, Type 2; Exercise; MicroRNAsen-US
dc.subjectDiabetes Mellitus, Type 2; Exercise; MicroRNAses-ES
dc.titleMICRORNAS: CIRCULATING BIOMARKERS IN TYPE 2 DIABETES MELLITUS AND PHYSICAL EXERCISEen-US
dc.titleMicroRNAs: marcadores séricos en Diabetes Mellitus tipo 2 y ejercicio físicoes-ES
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.typees-ES


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