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ASSOCIATION OF THE FTO (rs9939609) GENOTYPE WITH ENERGY INTAKE

Asociación entre el polimorfismo rs9939609 del gen FTO con la ingesta energética, macronutrientes y consumo de alcohol en población chilena.

dc.contributoren-US
dc.contributores-ES
dc.creatorVillagrán, Marcelo
dc.creatorPetermann, Fanny
dc.creatorMardones, Lorena
dc.creatorGarrido-Méndez, Alex
dc.creatorMartorell, Miquel
dc.creatorUlloa, Natalia
dc.creatorSantos, Jose Luis
dc.creatorPérez-Bravo, Francisco
dc.creatorCelis-Morales, Carlos; University of Glasgow
dc.date2018-11-22
dc.date.accessioned2019-11-11T18:26:56Z
dc.date.available2019-11-11T18:26:56Z
dc.identifierhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/view/6709
dc.identifier.urihttps://revistaschilenas.uchile.cl/handle/2250/110883
dc.descriptionBackground: Fat-mass-associated-gene (FTO) is associated with higher energy intake and specific food preferences. Aim: To investigate the association of the FTO genotype with energy intake, macronutrient and alcohol consumption. Material and methods: Four hundred and nine participants of the GENADIO (Genes, Environment, Diabetes and Obesity) study were included. Energy intake, macronutrient and alcohol consumption were the outcomes of interest. The association of FTO (rs9939609) genotype with these outcomes was investigated using linear regression analyses, adjusting for confounding variables. Results: After adjusting for socio-demographic factors, being a carrier of the risk allele for the FTO gene was associated with a higher energy intake (173 kcal per each extra copy of the risk variant [95% confidence intervals (CI): 45; 301] (P=0.008). After adjusting for lifestyle factors and body mass index, the association was slightly attenuated but remained significant (144 kcal [95% CI: 14; 274], p=0.030). Conclusions: The FTO genotype is associated with a higher energy intake.en-US
dc.descriptionBackground: Fat-mass-associated-gene (FTO) is associated with higher energy intake and specific food preferences. Aim: To investigate the association of the FTO genotype with energy intake, macronutrient and alcohol consumption. Material and methods: Four hundred and nine participants of the GENADIO (Genes, Environment, Diabetes and Obesity) study were included. Energy intake, macronutrient and alcohol consumption were the outcomes of interest. The association of FTO (rs9939609) genotype with these outcomes was investigated using linear regression analyses, adjusting for confounding variables. Results: After adjusting for socio-demographic factors, being a carrier of the risk allele for the FTO gene was associated with a higher energy intake (173 kcal per each extra copy of the risk variant [95% confidence intervals (CI): 45; 301] (P=0.008). After adjusting for lifestyle factors and body mass index, the association was slightly attenuated but remained significant (144 kcal [95% CI: 14; 274], p=0.030). Conclusions: The FTO genotype is associated with a higher energy intake.es-ES
dc.formatapplication/pdf
dc.languagespa
dc.publisherRevista Médica de Chilees-ES
dc.relationhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/view/6709/4451
dc.relationhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/downloadSuppFile/6709/34511
dc.relationhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/downloadSuppFile/6709/34512
dc.relationhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/downloadSuppFile/6709/34513
dc.relationhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/downloadSuppFile/6709/34514
dc.relationhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/downloadSuppFile/6709/34528
dc.relationhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/downloadSuppFile/6709/34886
dc.relationhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/downloadSuppFile/6709/34888
dc.relationhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/downloadSuppFile/6709/37264
dc.relationhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/downloadSuppFile/6709/37265
dc.relationhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/downloadSuppFile/6709/37266
dc.sourceRevista Médica de Chile; Vol. 146, núm. 11 (2018): NOVIEMBRE 2018es-ES
dc.source0034-9887
dc.subjectAlpha-Ketoglutarate-Dependent Dioxygenase; Diet; Energy Intake; FTO; Genotypeen-US
dc.subjectAlpha-Ketoglutarate-Dependent Dioxygenase; Diet; Energy Intake; FTO; Genotypees-ES
dc.titleASSOCIATION OF THE FTO (rs9939609) GENOTYPE WITH ENERGY INTAKEen-US
dc.titleAsociación entre el polimorfismo rs9939609 del gen FTO con la ingesta energética, macronutrientes y consumo de alcohol en población chilena.es-ES
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.typees-ES


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