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Leucemia de células plasmáticas primaria: experiencia en un hospital público chileno.

PRIMARY PLASMA CELL LEUKEMIA. REPORT OF FIVE CASES

dc.contributores-ES
dc.contributoren-US
dc.creatorMendoza, Maria Gabriela
dc.creatorValladares, Ximena
dc.creatorRoa, Macarena
dc.creatorReyes, Margarita
dc.creatorOsorio, Rocío
dc.creatorUndurraga, María Soledad
dc.creatorLegues, María Eugenia
dc.creatorCabrera, María Elena
dc.creatorPeña, Camila; Hospital del Salvador
dc.date2018-12-11
dc.date.accessioned2019-11-11T18:27:01Z
dc.date.available2019-11-11T18:27:01Z
dc.identifierhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/view/7040
dc.identifier.urihttps://revistaschilenas.uchile.cl/handle/2250/110943
dc.descriptionBackground: Primary plasma cell leukemia (pPCL) is uncommon, aggressive and has a different biology than multiple myeloma (MM). Aim: To report the features of patients with pPCL. Material and methods: Review of databases of the hematology department and the hematology laboratory. Results: Of 178 patients with monoclonal gammopathies, five (2.8%) patients aged 33 to 64 years (three females) had a LCPp. The mean hemoglobin was 7.3g /dL, the mean white blood cell count was 52,500 / mm3, with 58% plasma cells, and the mean platelet count was 83,600 / mm3. The mean bone marrow infiltration was 89%, LDH was 2003 IU / L, serum calcium was 13 mg/dL, and creatinine 1.5 mg/dL. Two patients had bone lesions. Three were IgG, one IgA Lambda and one Lambda light chain. CD20 was positive in one, CD56 was negative in all and CD117 was negative in 3 cases. By conventional cytogenetic analysis, two had a complex karyotype. By Fluorescence in situ Hybridization, one was positive for TP53 and another for t (11; 14). One patient did not receive any treatment, three patients received VTD PACE and one CTD. None underwent transplant. Three patients are alive. The mean survival was 14 months. Conclusions: These patients with pPCL were younger and had a more aggressive clinical outcome than in multiple myeloma.es-ES
dc.descriptionBackground: Primary plasma cell leukemia (pPCL) is uncommon, aggressive and has a different biology than multiple myeloma (MM). Aim: To report the features of patients with pPCL. Material and methods: Review of databases of the hematology department and the hematology laboratory. Results: Of 178 patients with monoclonal gammopathies, five (2.8%) patients aged 33 to 64 years (three females) had a LCPp. The mean hemoglobin was 7.3g /dL, the mean white blood cell count was 52,500 / mm3, with 58% plasma cells, and the mean platelet count was 83,600 / mm3. The mean bone marrow infiltration was 89%, LDH was 2003 IU / L, serum calcium was 13 mg/dL, and creatinine 1.5 mg/dL. Two patients had bone lesions. Three were IgG, one IgA Lambda and one Lambda light chain. CD20 was positive in one, CD56 was negative in all and CD117 was negative in 3 cases. By conventional cytogenetic analysis, two had a complex karyotype. By Fluorescence in situ Hybridization, one was positive for TP53 and another for t (11; 14). One patient did not receive any treatment, three patients received VTD PACE and one CTD. None underwent transplant. Three patients are alive. The mean survival was 14 months. Conclusions: These patients with pPCL were younger and had a more aggressive clinical outcome than in multiple myeloma.en-US
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dc.languagespa
dc.publisherRevista Médica de Chilees-ES
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dc.sourceRevista Médica de Chile; Vol. 147, núm. 1 (2019): ENERO 2019es-ES
dc.source0034-9887
dc.subjectBortezamib; Leukemia, Plasma Cell; Paraproteinemiases-ES
dc.subjectBortezamib; Leukemia, Plasma Cell; Paraproteinemiasen-US
dc.titleLeucemia de células plasmáticas primaria: experiencia en un hospital público chileno.es-ES
dc.titlePRIMARY PLASMA CELL LEUKEMIA. REPORT OF FIVE CASESen-US
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.typees-ES


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