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ACTIVE SEARCH OF CELIAC DISEASE AMONG FIRST DEGREE RELATIVES OF KNOWN CELIAC PATIENTS

Búsqueda activa de enfermedad celíaca en familiares de primer grado de casos celíacos

dc.contributoren-US
dc.contributorCorporación para Apoyo de la Investigación Científica en Nutrición (Cinut), Grifols® y Biodiagenees-ES
dc.creatorBejares, Marcela; Departamento de Pediatría Occidente, Hospital San Juan de Dios
dc.creatorOyarzún, Amaya
dc.creatorLucero, Yalda; Departamento de Pediatría Oriente, Hospital Luis Calvo Mackenna
dc.creatorEspinosa, Nelly; Unidad de Gastroenterología infantil, Hospital Militar
dc.creatorBascuñán, Karla; Programa de Doctorado en Nutrición y Alimentos, U Chile
dc.creatorAraya, Magdalena; INTA, Universidad de Chile
dc.date2015-11-27
dc.date.accessioned2019-11-11T18:27:02Z
dc.date.available2019-11-11T18:27:02Z
dc.identifierhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/view/4032
dc.identifier.urihttps://revistaschilenas.uchile.cl/handle/2250/110962
dc.descriptionBackground: Active search of celiac disease (CD) among risk groups has significantly increased the scope of known clinical variants. Aim: To measure the frequency and clinical characteristics of CD among first degree relatives (FDR) of known celiac cases. Material and methods: Between January 2012-August 2013, 37 patients with celiac disease brought 113 FDR for assessment. Their clinical data was recorded and a blood sample was obtained to measure serum Immunoglobulin A (IgA) levels, anti-transglutaminase (tTG) and anti-endomisial (EMA) antibodies. Cases with positive serology were advised to have an intestinal biopsy. Results: Fourteen relatives (12.4%) had positive serological results and none had IgA deficiency. Among IgA-tTG(-) cases, measurement of IgA/IgG-tTG identified an additional case. Two of the 14 relatives were EMA positive. All 14 cases were advised to have an intestinal biopsy, but only 6 accepted the procedure. In two, the intestinal lesion was classified Marsh ?2 and active CD was diagnosed. Histology in the remaining four was Marsh 0/1 and were diagnosed potential CD, remaining under control, without gluten free diet. Conclusions: Serological prevalence of CD among first degree relatives of known celiac cases was 15 fold greater than in THE general Chilean population, strongly supporting the idea of implementing active search to customary clinical practice. Determination of IgA/IgG-tTG may be useful to improve the yield of active search. Intestinal biopsies were crucial to differentiate active classic CD from potential CD.en-US
dc.descriptionBackground: Active search of celiac disease (CD) among risk groups has significantly increased the scope of known clinical variants. Aim: To measure the frequency and clinical characteristics of CD among first degree relatives (FDR) of known celiac cases. Material and methods: Between January 2012-August 2013, 37 patients with celiac disease brought 113 FDR for assessment. Their clinical data was recorded and a blood sample was obtained to measure serum Immunoglobulin A (IgA) levels, anti-transglutaminase (tTG) and anti-endomisial (EMA) antibodies. Cases with positive serology were advised to have an intestinal biopsy. Results: Fourteen relatives (12.4%) had positive serological results and none had IgA deficiency. Among IgA-tTG(-) cases, measurement of IgA/IgG-tTG identified an additional case. Two of the 14 relatives were EMA positive. All 14 cases were advised to have an intestinal biopsy, but only 6 accepted the procedure. In two, the intestinal lesion was classified Marsh ?2 and active CD was diagnosed. Histology in the remaining four was Marsh 0/1 and were diagnosed potential CD, remaining under control, without gluten free diet. Conclusions: Serological prevalence of CD among first degree relatives of known celiac cases was 15 fold greater than in THE general Chilean population, strongly supporting the idea of implementing active search to customary clinical practice. Determination of IgA/IgG-tTG may be useful to improve the yield of active search. Intestinal biopsies were crucial to differentiate active classic CD from potential CD.es-ES
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dc.languagespa
dc.publisherRevista Médica de Chilees-ES
dc.relationhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/view/4032/1671
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dc.relationhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/downloadSuppFile/4032/19969
dc.sourceRevista Médica de Chile; Vol. 143, núm. 12 (2015): DICIEMBRE 2015es-ES
dc.source0034-9887
dc.subjectCeliac Disease; Immunoglobulin A; Transglutaminase 2, humanen-US
dc.subjectCeliac Disease; Immunoglobulin A; Transglutaminase 2, humanes-ES
dc.titleACTIVE SEARCH OF CELIAC DISEASE AMONG FIRST DEGREE RELATIVES OF KNOWN CELIAC PATIENTSen-US
dc.titleBúsqueda activa de enfermedad celíaca en familiares de primer grado de casos celíacoses-ES
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.typees-ES


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