EFFECTS OF PREGNANCY AND CHANGES IN BODY WEIGHT ON POLYCYSTIC OVARY SYNDROME PHENOTYPES ACCORDING TO THE ROTTERDAM CRITERIA

Clasificación de los fenotipos de síndrome de ovario poliquístico de acuerdo a los criterios de Rotterdam : ¿una condición estática o variable?

Author
Echiburú, Bárbara; Universidad de Chile

Ladrón de Guevara, Amanda; Universidad de Chile

Pereira, Cecilia; Universidad de Chile

Pérez, Constanza; Universidad de Chile

Michael, Pía; Universidad de Chile

Crisosto, Nicolás; Universidad de Chile

Sir-Petermann, Teresa; Universidad de Chile

Full text
http://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/view/3384
Abstract
Background: Polycystic Ovary Syndrome (PCOS) is tightly associated with insulin resistance and obesity and characterized by hyperandrogenism, chronic oligo-anovulation and polycystic ovarian morphology when fully expressed. The 2003 Rotterdam consensus proposed that two or three of these features were necessary to make the diagnosis, which generated four phenotypes. Several studies have suggested that these phenotypes could differ in their metabolic and endocrine characteristics and that they could vary in the same patient when analyzed throughout life. Aim: To determine if the initial classification of PCOS phenotypes is modified by different physiological conditions. Material and methods: We performed a non-concurrent prospective analysis of 88 women with PCOS according to the Rotterdam criteria. The effect of physiological conditions such as changes in body weight, pregnancy and ageing more than five years on PCOS phenotype expression was analyzed. Results: Twenty four percent of women became pregnant, 37% decreased and 24% increased their body weight during follow up. These conditions modified significantly the proportion of the different phenotypes (?2=32.2, p
 
Background: Polycystic Ovary Syndrome (PCOS) is tightly associated with insulin resistance and obesity and characterized by hyperandrogenism, chronic oligo-anovulation and polycystic ovarian morphology when fully expressed. The 2003 Rotterdam consensus proposed that two or three of these features were necessary to make the diagnosis, which generated four phenotypes. Several studies have suggested that these phenotypes could differ in their metabolic and endocrine characteristics and that they could vary in the same patient when analyzed throughout life. Aim: To determine if the initial classification of PCOS phenotypes is modified by different physiological conditions. Material and methods: We performed a non-concurrent prospective analysis of 88 women with PCOS according to the Rotterdam criteria. The effect of physiological conditions such as changes in body weight, pregnancy and ageing more than five years on PCOS phenotype expression was analyzed. Results: Twenty four percent of women became pregnant, 37% decreased and 24% increased their body weight during follow up. These conditions modified significantly the proportion of the different phenotypes (?2=32.2, p
 
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