Bases fisiopatológicas para una clasificación de la neuropatía diabética.

Author
Olmos, Pablo R.; Pontificia Universidad Católica de Chile

Niklitschek, Sergio; Interno 7° año de Medicina, Alumno-ayudante, Facultad de Medicina, Pontificia Universidad Católica de Chile

Olmos, Roberto I; Interno 6° año de Medicina, Alumno-ayudante, Facultad de Medicina, Pontificia Universidad Católica de Chile

Faúndez, Jorge I; Alumno-ayudante, Facultad de Medicina, Pontificia Universidad Católica de Chile

Quezada, Thomas A; Alumno-ayudante, Facultad de Medicina, Pontificia Universidad Católica de Chile

Bozinovic, Milan A; Alumno-ayudante, Facultad de Medicina, Pontificia Universidad Católica de Chile

Niklitschek, Ian A; Alumno-ayudante, Facultad de Medicina, Pontificia Universidad Católica de Chile

Acosta, Jorge; Alumno-ayudante, Facultad de Medicina, Pontificia Universidad Católica de Chile

Valencia, Claudio N; Alumno-ayudante, Facultad de Medicina, Pontificia Universidad Católica de Chile

Bravo, Felipe A; Alumno-ayudante, Facultad de Medicina, Pontificia Universidad Católica de Chile

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http://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/view/1618
Abstract
A NEW PHYSIOPATHOLOGICAL CLASSIFICATION OF DIABETIC NEUROPATHY Nowadays, Diabetic Neuropathy (DN) is considered the most common cause of peripheral neuropathy in clinical practice. It can affect sensitive, motor or autonomic nerve fibers, with symmetric, asymmetric, acute or chronic presentations. Due to this variability, with multiple physiopathologic mechanisms involved, a complex clinical classification has been used until recently. The aim of this review is to present a new classification of diabetic neuropathy, based on its physiopathology. It is divided in metabolic microvascular and hypoxic, autoimmune and inflammatory, compressive, secondary to complications of diabetes and related to treatment. It must be understood that DN is not just a functional disease, but a complication of diabetes with molecular and pathological substrates caused by hyperglycemia.  Therefore, normalization of blood glucose is a fundamental step towards the successful prevention and treatment of DN.  
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