CLEFT LIP/PALATE AND FLOUR FORTIFICATION WITH FOLIC ACID IN CHILE. AN EXPLORATORY STUDY.

Fisuras labio-palatinas y fortificación de la harina con ácido fólico en Chile.

Author
Paulos, Angélica; Hospital Roberto del Rio Universidad de Chile

Pino, Paulina; Escuela de Salud Pública, Universidad de Chile Epidemióloga

Cavada, Gabriel; Escuela de Salud Pública, Universidad de Chile

Lagos, Carolina; Hospital Roberto del Rio Universidad de Chile

Broussain, Valentina; Hospital Roberto del Rio Universidad de Chile

Hasbun, Andrea; Hospital Roberto del Río Universidad de Chile

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http://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/view/4807
Abstract
Background: The effect of food fortification with folic acid on the incidence of lip-palate fissures (FLP) is under discussion. Aim: To calculate the rate of hospital discharges due to cleft lip and palate (CLP) and explore whether they decreased after the start of folic acid fortification in Chile. Material and methods: The hospital discharge databases published by the Chilean Ministry of Health were analyzed. The trends of discharge rates due CLP of children of less than one year of life (ICD-10 Q350-379 code) and live births (lb) were calculated from 1986 to 2012. Variables such as incidence of rubella, poverty rate, obesity in pregnant women, and percentage of women who smoked or drank alcohol in the last month were included. The relative risk (RR) of CLP pre-fortification (1986-1999) and post-fortification (2000-2010) was calculated. Mixed and Prais-Winsten models were used to adjust other variables. Results: The hospital discharge rate due to CLP decreased from 1.88 x 1000 lb during 1986-1996 to 1.68 x 1000 lb (RR = 1.09 (95% CI 1.05 - 1.14, p
 
Background: The effect of food fortification with folic acid on the incidence of lip-palate fissures (FLP) is under discussion. Aim: To calculate the rate of hospital discharges due to cleft lip and palate (CLP) and explore whether they decreased after the start of folic acid fortification in Chile. Material and methods: The hospital discharge databases published by the Chilean Ministry of Health were analyzed. The trends of discharge rates due CLP of children of less than one year of life (ICD-10 Q350-379 code) and live births (lb) were calculated from 1986 to 2012. Variables such as incidence of rubella, poverty rate, obesity in pregnant women, and percentage of women who smoked or drank alcohol in the last month were included. The relative risk (RR) of CLP pre-fortification (1986-1999) and post-fortification (2000-2010) was calculated. Mixed and Prais-Winsten models were used to adjust other variables. Results: The hospital discharge rate due to CLP decreased from 1.88 x 1000 lb during 1986-1996 to 1.68 x 1000 lb (RR = 1.09 (95% CI 1.05 - 1.14, p
 
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