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Epigenética del Síndrome de Ovario Poliquístico

EPIGENETICS OF POLYCYSTIC OVARY SYNDROME

dc.contributorFONDECYT 1151531 y 1130240es-ES
dc.contributoren-US
dc.creatorConcha C, Francisca
dc.creatorSir P, Teresa; Laboratorio de Endocrinología Facultad de Medicina Occidente Universidad de Chile
dc.creatorRecabarren, Sergio E; Universidad de Concepción
dc.creatorPérez B, Francisco; Departamento de Nutrición Facultad de Medicina Universidad de Chile
dc.date2017-07-05
dc.date.accessioned2019-11-11T18:27:09Z
dc.date.available2019-11-11T18:27:09Z
dc.identifierhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/view/4938
dc.identifier.urihttps://revistaschilenas.uchile.cl/handle/2250/110990
dc.descriptionPolycystic ovarian syndrome (PCOS) is an endocrine and metabolic dysfunction, highly prevalent in women in their reproductive years. Hyperandrogenism, oligo-ovulation, polycystic ovarian morphology are the main features of this syndrome. PCOS is a genetic disorder with a multifactorial etiology and has a strong link with environmental components. It is frequently associated with obesity and insulin resistance. Recently, epigenetic mechanisms have been involved in the pathogenesis of PCOS. Several studies showed that methylation in DNA and miRNAs is altered in women with PCOS in blood, serum, adipose tissue, granulose cells and theca. This evidence indicates that women with PCOS have a different epigenetic regulation, which might be triggered by an adverse intrauterine environment or by postnatal environmental elements such as diet and or obesity.es-ES
dc.descriptionPolycystic ovarian syndrome (PCOS) is an endocrine and metabolic dysfunction, highly prevalent in women in their reproductive years. Hyperandrogenism, oligo-ovulation, polycystic ovarian morphology are the main features of this syndrome. PCOS is a genetic disorder with a multifactorial etiology and has a strong link with environmental components. It is frequently associated with obesity and insulin resistance. Recently, epigenetic mechanisms have been involved in the pathogenesis of PCOS. Several studies showed that methylation in DNA and miRNAs is altered in women with PCOS in blood, serum, adipose tissue, granulose cells and theca. This evidence indicates that women with PCOS have a different epigenetic regulation, which might be triggered by an adverse intrauterine environment or by postnatal environmental elements such as diet and or obesity.en-US
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dc.languagespa
dc.publisherRevista Médica de Chilees-ES
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dc.sourceRevista Médica de Chile; Vol. 145, núm. 7 (2017): JULIO 2017es-ES
dc.source0034-9887
dc.subjectEpigenomics; Genes, Regulator; Polycystic Ovary Syndromees-ES
dc.subjectEpigenomics; Genes, Regulator; Polycystic Ovary Syndromeen-US
dc.titleEpigenética del Síndrome de Ovario Poliquísticoes-ES
dc.titleEPIGENETICS OF POLYCYSTIC OVARY SYNDROMEen-US
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.typees-ES


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