Show simple item record

ASSOCIATION OF THE TCF7L2 (RS7903146) GENOTYPE WITH ADIPOSITY AND METABOLIC MARKERS IN THE CHILEAN ADULT POPULATION

Asociación del gen TCF7L2 (rs7903146) con marcadores de adiposidad y metabólicos en población chilena – resultados del estudio GENADIO

dc.contributoren-US
dc.contributores-ES
dc.creatorPetermann-Rocha, Fanny
dc.creatorLasserre-Laso, Nicole
dc.creatorVillagrán, Marcelo
dc.creatorMardones, Lorena
dc.creatorMartínez, María Adela
dc.creatorLeiva, Ana María
dc.creatorUlloa, Natalia
dc.creatorCelis-Morales, Carlos; BHF Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow
dc.date2019-08-07
dc.date.accessioned2019-11-11T18:27:09Z
dc.date.available2019-11-11T18:27:09Z
dc.identifierhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/view/6894
dc.identifier.urihttps://revistaschilenas.uchile.cl/handle/2250/110995
dc.descriptionBackground: Type 2 diabetes etiology has a strong genetic component. More than 20 genetic variants have been associated with diabetes and other metabolic markers. However, the polymorphism rs7903146 of the TCF7L2 gene has shown the strongest association. Aim: To investigate the association of TCF7L2 (rs7903146) genotype with adiposity and metabolic markers in the Chilean adult population. Material and methods: The association of TCF7L2 (rs7093146) with adiposity and metabolic markers was studied in 301 participants. The outcomes of the study were adiposity markers (body weight, body mass index (BMI), fat mass and waist circumference) and metabolic markers (blood glucose, insulin, HOMA-IR, lipid profile, high sensitivity C-reactive protein (CRP), alanine aminotransferase (ALT), gamma glutamyl transpeptidase (GGT) and leptin). Results: There was an association between the polymorphism TCF7L2 genotype and fasting blood glucose. The latter increased by 4.86 mg/dl per each copy of the risk allele [(95% confidence intervals (CI): 0.48; 9.24), p=0.03] in the unadjusted adjusted model. However, this association was slightly attenuated in the fully adjusted model [4.38 mg/dl (95% IC: 0.16; 8.60), p=0.04). There were no associations between the TCF7L2 genotype and any other metabolic or adiposity outcome. Conclusions: These findings confirm the association between the TCF7L2 (rs7903146) and fasting glucose in the Chilean population. However, further studies are needed to confirm the association between the TCF7L2 and diabetes risk in the Chilean population.en-US
dc.descriptionBackground: Type 2 diabetes etiology has a strong genetic component. More than 20 genetic variants have been associated with diabetes and other metabolic markers. However, the polymorphism rs7903146 of the TCF7L2 gene has shown the strongest association. Aim: To investigate the association of TCF7L2 (rs7903146) genotype with adiposity and metabolic markers in the Chilean adult population. Material and methods: The association of TCF7L2 (rs7093146) with adiposity and metabolic markers was studied in 301 participants. The outcomes of the study were adiposity markers (body weight, body mass index (BMI), fat mass and waist circumference) and metabolic markers (blood glucose, insulin, HOMA-IR, lipid profile, high sensitivity C-reactive protein (CRP), alanine aminotransferase (ALT), gamma glutamyl transpeptidase (GGT) and leptin). Results: There was an association between the polymorphism TCF7L2 genotype and fasting blood glucose. The latter increased by 4.86 mg/dl per each copy of the risk allele [(95% confidence intervals (CI): 0.48; 9.24), p=0.03] in the unadjusted adjusted model. However, this association was slightly attenuated in the fully adjusted model [4.38 mg/dl (95% IC: 0.16; 8.60), p=0.04). There were no associations between the TCF7L2 genotype and any other metabolic or adiposity outcome. Conclusions: These findings confirm the association between the TCF7L2 (rs7903146) and fasting glucose in the Chilean population. However, further studies are needed to confirm the association between the TCF7L2 and diabetes risk in the Chilean population.es-ES
dc.formatapplication/pdf
dc.languagespa
dc.publisherRevista Médica de Chilees-ES
dc.relationhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/view/6894/5157
dc.relationhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/downloadSuppFile/6894/36013
dc.relationhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/downloadSuppFile/6894/36014
dc.relationhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/downloadSuppFile/6894/36015
dc.relationhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/downloadSuppFile/6894/36017
dc.relationhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/downloadSuppFile/6894/36701
dc.relationhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/downloadSuppFile/6894/39601
dc.relationhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/downloadSuppFile/6894/41093
dc.relationhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/downloadSuppFile/6894/41094
dc.relationhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/downloadSuppFile/6894/41095
dc.sourceRevista Médica de Chile; Vol. 147, núm. 8 (2019): AGOSTO 2019es-ES
dc.source0034-9887
dc.subjectAdiposity; Biomarkers; Diabetes Mellitus, Type 2; Genetics; Transcription Factor 7-Like 2 Proteinen-US
dc.subjectAdiposity; Biomarkers; Diabetes Mellitus, Type 2; Genetics; Transcription Factor 7-Like 2 Proteines-ES
dc.titleASSOCIATION OF THE TCF7L2 (RS7903146) GENOTYPE WITH ADIPOSITY AND METABOLIC MARKERS IN THE CHILEAN ADULT POPULATIONen-US
dc.titleAsociación del gen TCF7L2 (rs7903146) con marcadores de adiposidad y metabólicos en población chilena – resultados del estudio GENADIOes-ES
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.typees-ES


This item appears in the following Collection(s)

Show simple item record