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MANAGEMENT OF SEVERE ULCERATIVE COLITIS. AN UPDATE

Diagnóstico y Manejo de Colitis Ulcerosa Grave. Una Mirada Actualizada

dc.contributoren-US
dc.contributorFondo Nacional de Ciencia y Tecnología de Chile (FONDECYT) y Pontificia Universidad Católica de Chilees-ES
dc.creatorHernández-Rocha, Cristian; Pontificia Universidad Católica de Chile
dc.creatorIbáñez, Patricio
dc.creatorMolina, María Elena
dc.creatorKlaassen, Julieta
dc.creatorValenzuela, Andrea
dc.creatorCandia, Roberto
dc.creatorBellolio, Felipe
dc.creatorZúñiga, Álvaro
dc.creatorMiguieles, Rodrigo
dc.creatorMiquel, Juan Francisco
dc.creatorChianale, José
dc.creatorÁlvarez-Lobos, Manuel
dc.date2016-12-27
dc.date.accessioned2019-11-11T18:27:12Z
dc.date.available2019-11-11T18:27:12Z
dc.identifierhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/view/4509
dc.identifier.urihttps://revistaschilenas.uchile.cl/handle/2250/111030
dc.descriptionUlcerative Colitis (UC) is a chronic inflammatory disease involving the colon, with alternating periods of remission and activity. Exacerbations can be severe and associated with complications and mortality. Diagnosis of severe UC is based on clinical, biochemical and endoscopic variables. Patients with severe UC must be hospitalized. First line therapy is the use of intravenous corticoids which achieve clinical remission in most patients. However, 25% of patients will be refractory to corticoids, situation that should be evaluated at the third day of therapy. In patients without response, cytomegalovirus infection must be quickly ruled out to escalate to second line therapy with biological drugs or cyclosporine. Total colectomy must not be delayed if there is no response to second line therapy, if there is a contraindication for second line therapies or there are complications such as: megacolon, perforation or massive bleeding. An active management with quick escalation on therapy allows to decrease the prolonged exposure to corticoids, reduce colectomy rates and its perioperative complications.en-US
dc.descriptionUlcerative Colitis (UC) is a chronic inflammatory disease involving the colon, with alternating periods of remission and activity. Exacerbations can be severe and associated with complications and mortality. Diagnosis of severe UC is based on clinical, biochemical and endoscopic variables. Patients with severe UC must be hospitalized. First line therapy is the use of intravenous corticoids which achieve clinical remission in most patients. However, 25% of patients will be refractory to corticoids, situation that should be evaluated at the third day of therapy. In patients without response, cytomegalovirus infection must be quickly ruled out to escalate to second line therapy with biological drugs or cyclosporine. Total colectomy must not be delayed if there is no response to second line therapy, if there is a contraindication for second line therapies or there are complications such as: megacolon, perforation or massive bleeding. An active management with quick escalation on therapy allows to decrease the prolonged exposure to corticoids, reduce colectomy rates and its perioperative complications.es-ES
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dc.languagespa
dc.publisherRevista Médica de Chilees-ES
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dc.sourceRevista Médica de Chile; Vol. 145, núm. 1 (2017): ENERO 2017es-ES
dc.source0034-9887
dc.subjectColitis, Ulcerative; Colonic Diseases; Diagnosis; Drug Therapy; Inflammatory Bowel Diseasesen-US
dc.subjectColitis, Ulcerative; Colonic Diseases; Diagnosis; Drug Therapy; Inflammatory Bowel Diseaseses-ES
dc.titleMANAGEMENT OF SEVERE ULCERATIVE COLITIS. AN UPDATEen-US
dc.titleDiagnóstico y Manejo de Colitis Ulcerosa Grave. Una Mirada Actualizadaes-ES
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.typees-ES


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