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SIROLIMUS AND PREDNISONE FOR THE TREATMENT OF ERDHEIM-CHESTER DISEASE WITH CARDIAC INVOLVEMENT. REPORT OF ONE CASE.

Tratamiento con sirolimus y prednisona en enfermedad de Erdheim-Chester con compromiso cardíaco. Caso Clínico

dc.contributoren-US
dc.contributorNingunaes-ES
dc.creatorVega, Jorge; Escuela de Medicina Universidad de Valparaíso; Hospital Naval A. Nef; Hospital Dr. Gustavo Fricke
dc.creatorSantamarina, Mario; Servicio de Radiologia, Hospital Naval A. Nef, Viña del Mar
dc.date2016-03-03
dc.date.accessioned2019-11-11T18:27:14Z
dc.date.available2019-11-11T18:27:14Z
dc.identifierhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/view/4584
dc.identifier.urihttps://revistaschilenas.uchile.cl/handle/2250/111043
dc.descriptionErdheim-Chester disease (ECD) is a rare non-Langerhans histiocytic disorder. We report a 76-years-old man who suffered a cardiac tamponade secondary to ECD. A pericardial window was made and during the operation the surgeons observed that the myocardium was diffusely infiltrated. Twenty-eight months before, ECD was clinically diagnosed and prednisone and methotrexate were prescribed. Due to disease progression which culminated in the cardiac tamponade, methotrexate was changed to sirolimus aiming to obtain plasma levels between 5-8 ng/ml. This treatment stabilized his cardiac function allowing a survival of 52 months after its initiation, with fewer side effects.en-US
dc.descriptionErdheim-Chester disease (ECD) is a rare non-Langerhans histiocytic disorder. We report a 76-years-old man who suffered a cardiac tamponade secondary to ECD. A pericardial window was made and during the operation the surgeons observed that the myocardium was diffusely infiltrated. Twenty-eight months before, ECD was clinically diagnosed and prednisone and methotrexate were prescribed. Due to disease progression which culminated in the cardiac tamponade, methotrexate was changed to sirolimus aiming to obtain plasma levels between 5-8 ng/ml. This treatment stabilized his cardiac function allowing a survival of 52 months after its initiation, with fewer side effects.es-ES
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dc.languagespa
dc.publisherRevista Médica de Chilees-ES
dc.relationhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/view/4584/1905
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dc.relationhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/downloadSuppFile/4584/21503
dc.sourceRevista Médica de Chile; Vol. 144, núm. 3 (2016): MARZO 2016es-ES
dc.source0034-9887
dc.subjectCardiac Tamponade; Erdheim-Chester Disease; Heart Failure; Sirolimusen-US
dc.subjectCardiac Tamponade; Erdheim-Chester Disease; Heart Failure; Sirolimuses-ES
dc.titleSIROLIMUS AND PREDNISONE FOR THE TREATMENT OF ERDHEIM-CHESTER DISEASE WITH CARDIAC INVOLVEMENT. REPORT OF ONE CASE.en-US
dc.titleTratamiento con sirolimus y prednisona en enfermedad de Erdheim-Chester con compromiso cardíaco. Caso Clínicoes-ES
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.typees-ES


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