METFORMIN-ASSOCIATED LACTIC ACIDOSIS. REPORT OF ONE CASE
Acidosis láctica asociada a metformina.Caso Clínico
Author
Quintana, Felipe; Facultad de Medicina, Universidad Finis Terrae
Pezzani, María José; Facultad de Medicina, Universidad Finis Terrae
Orozco, Rodrigo; Unidad de Nefrología, Clinica las Condes
Dreyse, Jorge; Centro de Pacientes Críticos, Clinica las Condes
Soto, Leonardo; Centro de Pacientes Críticos, Clinica las Condes
Regueira, Tomás; Centro de Pacientes Críticos, Clinica las Condes
Abstract
Metformin-associated lactic acidosis is a severe and infrequent adverse event. Early diagnosis is essential to start an early treatment, which often has favorable results. We report a 56 years old non-insulin-requiring type 2 diabetic female who developed a severe metabolic acidosis associated with metformin in relation to an acute renal failure secondary to infectious diarrhea. Early treatment with bicarbonate and continuous hemofiltration allowed a quick improvement of the patient. Metformin-associated lactic acidosis has an elevated mortality (50-80%) and has a specific and effective treatment. Therefore, the condition must be born in mind. Metformin-associated lactic acidosis is a severe and infrequent adverse event. Early diagnosis is essential to start an early treatment, which often has favorable results. We report a 56 years old non-insulin-requiring type 2 diabetic female who developed a severe metabolic acidosis associated with metformin in relation to an acute renal failure secondary to infectious diarrhea. Early treatment with bicarbonate and continuous hemofiltration allowed a quick improvement of the patient. Metformin-associated lactic acidosis has an elevated mortality (50-80%) and has a specific and effective treatment. Therefore, the condition must be born in mind.