ACQUIRED APLASTIC ANEMIA DURING PREGNANCY. REPORT OF ONE CASE

Aplasia medular adquirida y embarazo, a propósito de un caso

Author
León, Pilar; Universidad de Chile

Lería, Josefina; Universidad de Chile

Cardemil, Daniela; Universidad de Chile

Díaz, Angélica; Hospital Dr. Luis Tisné

Hernández, Miguelina; Hospital Dr. Luis Tisné

Chubretovic, Magdalena; Universidad de Chile

González, Josefa; Universidad de Chile

Cabrera, María Elena; Hospital del Salvador

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http://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/view/5773
Abstract
Aplastic anemia (AA) or acquired aplastic anemia is an uncommon and potentially fatal disease. It is defined as reduction of at least two peripheral blood series, associated with persistent bone marrow hypocellularity. It’s association with pregnancy is even more uncommon, and it may result in high mortality for the mother and the child. We report an adolescent female with aplastic anemia, which worsened during pregnancy. Her hemoglobin was 5.2 g/dl, her leukocytes were 1833/ul and her platelets were 19000/ul. She was initially treated with cyclosporine and horse antithymocyte globulin without hematologic improvement. At 36 weeks of pregnancy methylprednisolone and platelet transfusions were used and a cesarean section was performed. Six month later she continues to require red blood cell and platelet transfusions.
 
Aplastic anemia (AA) or acquired aplastic anemia is an uncommon and potentially fatal disease. It is defined as reduction of at least two peripheral blood series, associated with persistent bone marrow hypocellularity. It’s association with pregnancy is even more uncommon, and it may result in high mortality for the mother and the child. We report an adolescent female with aplastic anemia, which worsened during pregnancy. Her hemoglobin was 5.2 g/dl, her leukocytes were 1833/ul and her platelets were 19000/ul. She was initially treated with cyclosporine and horse antithymocyte globulin without hematologic improvement. At 36 weeks of pregnancy methylprednisolone and platelet transfusions were used and a cesarean section was performed. Six month later she continues to require red blood cell and platelet transfusions.
 
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