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IMPORTANCE OF RESPIRATORY VIRUS IN IMMUNOCOMPETENT ADULT PATIENTS HOSPITALIZED WITH COMMUNITY-ACQUIRED PNEUMONIA.

Participación de los virus respiratorios en la neumonía del adulto inmunocompetente adquirida en la comunidad.

dc.contributoren-US
dc.contributorFuente de financiamiento: Proyecto Interdepartamental de la Facultad de Medicina, P. Universidad Católica de Chile.es-ES
dc.creatorSaldías Peñafiel, Fernando; Neumotisiología Medicina PUC
dc.creatorOrtega Gutiérrez, Marcos; Pontificia Universidad Católica de Chile
dc.creatorFuentes López, Gino; Universidad Austral de Chile.
dc.creatorElola Aránguiz, José Manuel; Pontificia Universidad Capólica de Chile.
dc.creatorUribe Monasterio, Javier; Pontificia Universidad Católica de Chile.
dc.creatorMorales Soto, Arturo; Pontificia Universidad Católica de Chile.
dc.creatorDíaz Patiño, Orlando; Pontificia Universidad Católica de Chile.
dc.date2016-12-14
dc.date.accessioned2019-11-11T18:27:25Z
dc.date.available2019-11-11T18:27:25Z
dc.identifierhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/view/5212
dc.identifier.urihttps://revistaschilenas.uchile.cl/handle/2250/111121
dc.descriptionBackground: Community-acquired pneumonia (CAP) is a relevant worldwide cause of morbidity and mortality in adult population, however its etiology is often not identified and therapy is empirical. Aim: To assess the etiology of CAP in immunocompetent adult hospitalized patients using conventional and molecular diagnostic methods. Material and methods: We prospectively studied 240 adult patients who were hospitalized for CAP to identify the microbial etiology. Sputum and blood cultures were obtained as well as serology testing for Mycoplasma pneumoniae and Chlamydophila pneumoniae, urinary antigen testing for Legionella pneumophila and Streptococcus pneumoniae, and a nasopharyngeal swab for the detection of sixteen respiratory viruses by reverse transcriptase polymerase chain reaction (RT-PCR). Results: In 100 patients (41.7%) a single respiratory pathogen was identified. In 17 (7.1%) cases, a mixed bacterial and viral infection was detected and no pathogen was identified in 123 cases (51%). The most commonly identified pathogens identified were: influenza virus (15.4%), parainfluenza virus (10.8%), rhinovirus (5%), Streptococcus pneumoniae (5%), respiratory syncytial virus (2.9%) and Mycoplasma pneumoniae (2.5%). Infectious agent detection by RT-PCR provided greater sensitivity than conventional techniques. Viral respiratory infections were more prevalent in older patients with comorbidities and high risk patients, according to the Fine index at hospital admission. The clinical severity and outcome were independent of the etiological agents detected. Conclusions: The use of molecular diagnostic techniques expanded the detection of respiratory viruses in immunocompetent adults hospitalized with CAP.en-US
dc.descriptionBackground: Community-acquired pneumonia (CAP) is a relevant worldwide cause of morbidity and mortality in adult population, however its etiology is often not identified and therapy is empirical. Aim: To assess the etiology of CAP in immunocompetent adult hospitalized patients using conventional and molecular diagnostic methods. Material and methods: We prospectively studied 240 adult patients who were hospitalized for CAP to identify the microbial etiology. Sputum and blood cultures were obtained as well as serology testing for Mycoplasma pneumoniae and Chlamydophila pneumoniae, urinary antigen testing for Legionella pneumophila and Streptococcus pneumoniae, and a nasopharyngeal swab for the detection of sixteen respiratory viruses by reverse transcriptase polymerase chain reaction (RT-PCR). Results: In 100 patients (41.7%) a single respiratory pathogen was identified. In 17 (7.1%) cases, a mixed bacterial and viral infection was detected and no pathogen was identified in 123 cases (51%). The most commonly identified pathogens identified were: influenza virus (15.4%), parainfluenza virus (10.8%), rhinovirus (5%), Streptococcus pneumoniae (5%), respiratory syncytial virus (2.9%) and Mycoplasma pneumoniae (2.5%). Infectious agent detection by RT-PCR provided greater sensitivity than conventional techniques. Viral respiratory infections were more prevalent in older patients with comorbidities and high risk patients, according to the Fine index at hospital admission. The clinical severity and outcome were independent of the etiological agents detected. Conclusions: The use of molecular diagnostic techniques expanded the detection of respiratory viruses in immunocompetent adults hospitalized with CAP.es-ES
dc.formatapplication/pdf
dc.languagespa
dc.publisherRevista Médica de Chilees-ES
dc.relationhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/view/5212/2657
dc.relationhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/downloadSuppFile/5212/24479
dc.relationhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/downloadSuppFile/5212/24480
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dc.relationhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/downloadSuppFile/5212/24484
dc.relationhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/downloadSuppFile/5212/24485
dc.relationhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/downloadSuppFile/5212/24486
dc.relationhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/downloadSuppFile/5212/24531
dc.relationhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/downloadSuppFile/5212/26015
dc.relationhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/downloadSuppFile/5212/27335
dc.sourceRevista Médica de Chile; Vol. 144, núm. 12 (2016): DICIEMBRE 2016es-ES
dc.source0034-9887
dc.subjectMolecular Diagnostic Techniques; Pathology, Molecular; Pneumonia; Pneumonia, Viralen-US
dc.subjectMolecular Diagnostic Techniques; Pathology, Molecular; Pneumonia; Pneumonia, Virales-ES
dc.titleIMPORTANCE OF RESPIRATORY VIRUS IN IMMUNOCOMPETENT ADULT PATIENTS HOSPITALIZED WITH COMMUNITY-ACQUIRED PNEUMONIA.en-US
dc.titleParticipación de los virus respiratorios en la neumonía del adulto inmunocompetente adquirida en la comunidad.es-ES
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.typees-ES


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