| dc.contributor | | es-ES |
| dc.creator | Cabezón, Mario; Unidad de Medicina Basada en Evidencia, Escuela de Medicina, Pontificia Universidad Católica de Chile.
Ayudante | |
| dc.creator | Rada, Gabriel; Unidad de Medicina Basada en Evidencia, Escuela de Medicina, Pontificia Universidad Católica de Chile.
Departamento de Medicina Interna, Pontificia Universidad Católica de Chile.
Unidad Docente Asociada, Hospital Dr. Sótero del Río. | |
| dc.date | 2011-05-18 | |
| dc.date.accessioned | 2019-11-11T18:27:28Z | |
| dc.date.available | 2019-11-11T18:27:28Z | |
| dc.identifier | http://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/view/1371 | |
| dc.identifier.uri | https://revistaschilenas.uchile.cl/handle/2250/111171 | |
| dc.description | Context: Computed tomographic (CT) colonography has been recognized as an alternativefor colorectal cancer (CRC) screening in average-risk individuals, but less information is available on its performance in individuals at increased risk of CRC. Objective: To assess the accuracy of CT colonography in detecting advanced colorectal neoplasia in asymptomatic individuals at increased risk of CRC using unblinded colonoscopy as the reference standard. Design, Setting, and Participants: This was a multicenter, cross-sectional study. Individuals at increased risk of CRC due to either family history of advanced neoplasia in first-degree relatives, personal history of colorectal adenomas, or positive results from fecal occult blood tests (FOBTs) were recruited in 11 Italian centers and 1 Belgian center between December 2004 and May 2007. Each participant underwent CT colonography followed by colonoscopy on the same day. Main Outcome Measures: Sensitivity and specificity of CT colonography in detecting individuals with advanced neoplasia (ie, advanced adenoma or CRC) 6 mm or larger. Results: Of 1103 participants, 937 were included in the final analysis: 373 cases in the family-history group, 343 in the group with personal history of adenomas, and 221 in the FOBT-positive group. Overall, CT colonography identified 151 of 177 participants with advanced neoplasia 6 mm or larger (sensitivity, 85.3%; 95% confidence interval [CI], 79.0%-90.0%) and correctly classified results as negative for 667 of 760 participants without such lesions (specificity, 87.8%; 95% CI, 85.2%-90.0%). The positive and negative predictive values were 61.9% (95% CI, 55.4%-68.0%) and 96.3% (95% CI, 94.6%-97.5%), respectively; after group stratification, a significantly lower negative predictive value was found for the FOBT-positive group (84.9%; 95% CI, 76.2%-91.3%; P_.001). Conclusions In a group of persons at increased risk for CRC, CT colonography compared with colonoscopy resulted in a negative predictive value of 96.3% overall. When limited to FOBT-positive persons, the negative predictive value was 84.9%. | es-ES |
| dc.language | es | |
| dc.publisher | Revista Médica de Chile | es-ES |
| dc.relation | http://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/downloadSuppFile/1371/2074 | |
| dc.relation | http://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/downloadSuppFile/1371/2385 | |
| dc.relation | http://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/downloadSuppFile/1371/2386 | |
| dc.source | Revista Médica de Chile; Vol. 139, núm. 5 (2011): MAYO 2011 | es-ES |
| dc.source | 0034-9887 | |
| dc.subject | | es-ES |
| dc.title | Colonografía por tomografía computada tuvo buen rendimiento para la pesquisa de cáncer colorrectal en pacientes de alto riesgo. | es-ES |
| dc.type | info:eu-repo/semantics/article | |
| dc.type | info:eu-repo/semantics/publishedVersion | |
| dc.type | | es-ES |
