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Tumor inflamatorio miofibroblástico peritoneal. Respuesta favorable asociada a infliximab Caso Clínico.

PERITONEAL MYOFIBROBLASTIC TUMOR SUCCESSFULLY TREATED WITH INFLIXIMAB. REPORT OF ONE CASE

dc.contributores-ES
dc.contributoren-US
dc.creatorGrunholz, Daniela; Hospital Militar de Santiago
dc.creatorAppiani, Franco; Hospital Militar de Santiago
dc.creatorAbarca, Constanza; Hospital Militar de Santiago
dc.creatorManríquez, María; Hospital Militar de Santiago
dc.creatorPinilla, Jorge; Hospital Militar de Santiago
dc.creatorWainstein, Eduardo; Hospital Militar de Santiago
dc.date2015-07-10
dc.date.accessioned2019-11-11T18:27:36Z
dc.date.available2019-11-11T18:27:36Z
dc.identifierhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/view/3954
dc.identifier.urihttps://revistaschilenas.uchile.cl/handle/2250/111208
dc.descriptionMyofibroblastic tumor (MIT) is characterized by the infiltration of different organs, most commonly the lungs, with nodular lesions composed of myofibroblasts and inflammatory cells, which can be identified by specific patterns in the immunohistochemical studies. When it involves the peritoneum it is difficult to eradicate, tends to relapse and it has an invasive behavior, requiring its differentiation from peritoneal carcinomatosis. Treatment may be surgical excision, the use of non-steroidal anti-inflammatory drugs (NSAIDs) and glucocorticoids. We report a 30 years old female with an unremarkable medical history, presenting with abdominal pain and progressive abdominal distention. A CT scan revealed multiple peritoneal nodular lesions. A surgical biopsy was reported as a myofibroblast and inflammatory cell infiltrate. Immunohistochemical staining was consistent with MIT. Given the extensive involvement of the peritoneum surgical therapy was not considered appropriate and treatment with NSAID and glucocorticoids was started. No response was observed after 6 months, therefore infliximab therapy was started. After 10 months of follow-up the patient is well, returned to normal life, ascites improved and resolved and CT scan showed partial regression or stabilization of the lesions.es-ES
dc.descriptionMyofibroblastic tumor (MIT) is characterized by the infiltration of different organs, most commonly the lungs, with nodular lesions composed of myofibroblasts and inflammatory cells, which can be identified by specific patterns in the immunohistochemical studies. When it involves the peritoneum it is difficult to eradicate, tends to relapse and it has an invasive behavior, requiring its differentiation from peritoneal carcinomatosis. Treatment may be surgical excision, the use of non-steroidal anti-inflammatory drugs (NSAIDs) and glucocorticoids. We report a 30 years old female with an unremarkable medical history, presenting with abdominal pain and progressive abdominal distention. A CT scan revealed multiple peritoneal nodular lesions. A surgical biopsy was reported as a myofibroblast and inflammatory cell infiltrate. Immunohistochemical staining was consistent with MIT. Given the extensive involvement of the peritoneum surgical therapy was not considered appropriate and treatment with NSAID and glucocorticoids was started. No response was observed after 6 months, therefore infliximab therapy was started. After 10 months of follow-up the patient is well, returned to normal life, ascites improved and resolved and CT scan showed partial regression or stabilization of the lesions.en-US
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dc.languagespa
dc.publisherRevista Médica de Chilees-ES
dc.relationhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/view/3954/1356
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dc.relationhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/downloadSuppFile/3954/19799
dc.sourceRevista Médica de Chile; Vol. 143, núm. 7 (2015): JULIO 2015es-ES
dc.source0034-9887
dc.subjectAnti-inflammatory agents; Inflammatory neoplasms; Infliximab; Non-steroidal clooxygenase-2 inhibitorses-ES
dc.subjectAnti-inflammatory agents; Inflammatory neoplasms; Infliximab; Non-steroidal clooxygenase-2 inhibitorsen-US
dc.titleTumor inflamatorio miofibroblástico peritoneal. Respuesta favorable asociada a infliximab Caso Clínico.es-ES
dc.titlePERITONEAL MYOFIBROBLASTIC TUMOR SUCCESSFULLY TREATED WITH INFLIXIMAB. REPORT OF ONE CASEen-US
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.typees-ES


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