Insulinemia e índice HOMA en niños y adolescentes chilenos.

Author
Barja, Salesa; Departamentos de: PediatríaFacultad de Medicina. Pontificia Universidad Católica de Chile.

Arnaiz, Pilar; Departamentos de: PediatríaFacultad de Medicina. Pontificia Universidad Católica de Chile.

Domínguez, Angélica; Licenciada en MatemáticasSalud PúblicaFacultad de Medicina. Pontificia Universidad Católica de Chile.

Villarroel, Luis; Doctor en Estadística. Salud PúblicaFacultad de Medicina. Pontificia Universidad Católica de Chile.

Cassis, Berta; Enfermera UniversitariaSalud PúblicaFacultad de Medicina. Pontificia Universidad Católica de Chile.

Castillo, Oscar; Nutricionista.Nutricion.Facultad de Medicina. Pontificia Universidad Católica de Chile.

Salomó, Gianina; Nutricionista.Salud PúblicaFacultad de Medicina. Pontificia Universidad Católica de Chile.

Farías, Marcelo; Ginecología y ObstetriciaFacultad de Medicina. Pontificia Universidad Católica de Chile.

Goycoolea, Manuela; Bioquímica. Laboratorios ClínicosFacultad de Medicina. Pontificia Universidad Católica de Chile.

Quiroga, Teresa; Laboratorios ClínicosFacultad de Medicina. Pontificia Universidad Católica de Chile.

Mardones, Francisco; Facultad de Medicina. Pontificia Universidad Católica de Chile.

Full text
http://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/view/1286
Abstract
NORMAL PLASMA INSULIN AND HOMA VALUES AMONG CHILEAN CHILDREN AND ADOLESCENTS Background: Plasma insulin and HOMA (homeostasis model assessment) index, used to determine insulin resistance, do not have local standard values for children and adolescents in Chile. Aim: To establish the normal reference intervals for insulin and HOMA in children and adolescents aged 10-15 years old, according to sex and puberal maturation. Material and methods: A cross-sectional study of 2,153 children and adolescents from Puente Alto County was performed, during 2009 and 2010. Anthropometry and self-report of puberal maturation were assessed. Fasting glucose (hexoquinase) and insulin blood levels (chemiluminiscence), were determined and HOMA index was calculated. Percentile distributions of these variables were calculated. Results: The reference group included only subjects with normal body mass index and fasting blood glucose (n=1,192). Women had higher insulin and HOMA values than men (12.5±6.0 and  9.1±4.9 ?U/mL (p< 0.01) and 2.7±1.4 and 2.1±1,1 (p< 0.01), respectively). Subjects with Tanner I and II puberal stages had lower insulin and HOMA mean values than subjects with Tanner III and IV:  9.0±4.3 and 12.5±6.2 µU/ml (p
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