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CONVENTIONAL SERUM TUMOR MARKERS IN LIVER CANCER. RETROSPECTIVE ANALYSIS OF 118 PATIENTS

Rendimiento diagnóstico de marcadores tumorales séricos convencionales en pacientes con sospecha clínica de cáncer primario metastásico a hígado

dc.contributoren-US
dc.contributorNingunaes-ES
dc.creatorArias-Flórez, Juan Sebatián; Universidad Industrial de Santander
dc.creatorMartínez-Delgado, Angélica María; Universidad Industrial de Santander
dc.creatorAlarcón-Tarazona, Martha Liliana; Universidad Industrial de Santander Hospital Universitario de Santander
dc.creatorInsuasty-Enriquez, Jesús Solier; Universidad Industrial de Santander Hospital Universitario de Santander
dc.creatorDiaz-Martínez, Luis Alfonso; Universidad Industrial de Santander
dc.date2018-11-23
dc.date.accessioned2019-11-11T18:27:52Z
dc.date.available2019-11-11T18:27:52Z
dc.identifierhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/view/6774
dc.identifier.urihttps://revistaschilenas.uchile.cl/handle/2250/111327
dc.descriptionBackground: Conventional serum tumor markers (CSTM) are widely used for monitoring patients with cancer. However, their usefulness as a diagnostic tool is controversial in primary or metastatic liver cancer (PMLC). Aim: To evaluate the diagnostic performance of the most commonly requested CSTM in the diagnostic approach of PMLC. Material and methods: Review of medical records of patients aged over 18 years with a liver biopsy, attended from 2005 to 2017 in a tertiary hospital and a regional cancer center in Colombia. The results of liver biopsies were compared with tumor markers such as carcinoembryonic antigen (CEA), alpha-fetoprotein (AFP), CA 19-9, CA 125 and prostate specific antigen (PSA) using a receiver operating characteristic (ROC) curve analysis. Results: We reviewed 2063 medical records and retrieved 118 eligible patients (59 cases and 59 controls, 70% males). Thirty percent had obstructive jaundice. There was heterogeneity in the amount of tumor markers requested according to medical criteria. Only CA 19-9 showed discriminative capacity (? 17.6 U / m), with a cut-off point lower than that reported in the literature and a sensitivity of 69.5%, specificity of 91.6%, a positive likelihood ratio (LR) of 8.32, and a negative LR of 0.33. Conclusions: Except for CA 19-9, tumor markers were not useful for the initial diagnostic approach in patients with suspected primary or metastatic malignant liver tumors.en-US
dc.descriptionBackground: Conventional serum tumor markers (CSTM) are widely used for monitoring patients with cancer. However, their usefulness as a diagnostic tool is controversial in primary or metastatic liver cancer (PMLC). Aim: To evaluate the diagnostic performance of the most commonly requested CSTM in the diagnostic approach of PMLC. Material and methods: Review of medical records of patients aged over 18 years with a liver biopsy, attended from 2005 to 2017 in a tertiary hospital and a regional cancer center in Colombia. The results of liver biopsies were compared with tumor markers such as carcinoembryonic antigen (CEA), alpha-fetoprotein (AFP), CA 19-9, CA 125 and prostate specific antigen (PSA) using a receiver operating characteristic (ROC) curve analysis. Results: We reviewed 2063 medical records and retrieved 118 eligible patients (59 cases and 59 controls, 70% males). Thirty percent had obstructive jaundice. There was heterogeneity in the amount of tumor markers requested according to medical criteria. Only CA 19-9 showed discriminative capacity (? 17.6 U / m), with a cut-off point lower than that reported in the literature and a sensitivity of 69.5%, specificity of 91.6%, a positive likelihood ratio (LR) of 8.32, and a negative LR of 0.33. Conclusions: Except for CA 19-9, tumor markers were not useful for the initial diagnostic approach in patients with suspected primary or metastatic malignant liver tumors.es-ES
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dc.languagespa
dc.publisherRevista Médica de Chilees-ES
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dc.sourceRevista Médica de Chile; Vol. 146, núm. 12 (2018): DICIEMBRE 2018es-ES
dc.source0034-9887
dc.subjectBiomarkers, Tumor; Liver Neoplasms; Mass Screeningen-US
dc.subjectBiomarkers, Tumor; Liver Neoplasms; Mass Screeninges-ES
dc.titleCONVENTIONAL SERUM TUMOR MARKERS IN LIVER CANCER. RETROSPECTIVE ANALYSIS OF 118 PATIENTSen-US
dc.titleRendimiento diagnóstico de marcadores tumorales séricos convencionales en pacientes con sospecha clínica de cáncer primario metastásico a hígadoes-ES
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.typees-ES


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