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REVERSION OF METHACHOLINE INDUCED BRONCHOCONSTRICTION WITH INHALED DIAZEPAM IN PATIENTS WITH ASTHMA

The bronchodilatory effect of benzodiazepines on bronchoconstriction induced by methacholine in patients diagnosed with asthma

dc.contributoren-US
dc.contributores-ES
dc.creatorMiric, Mirjana
dc.creatorRistic, Sinisa; Medical faculty Foca, University of East Sarajevo, Republic of Srpska, Bosnia and Herzegovina
dc.creatorJoksimovic, Bojan; Medical Faculty Foca, University of East Sarajevo, Republic of Srpska, Bosnia and Herzegovina, Department of pathological physiology
dc.creatorMedenica, Snezana; Medical Faculty Foca, University of East Sarajevo, Republic of Srpska, Bosnia and Herzegovina, Department of pathological physiology
dc.creatorRacic, Maja; Medical Faculty Foca, University of East Sarajevo, Republic of Srpska, Bosnia and Herzegovina
dc.creatorRistic, Slavica
dc.creatorJoksimovic, Vedrana R.; Medical Faculty Foca, University of East Sarajevo, Republic of Srpska, Bosnia and Herzegovina
dc.creatorSkipina, Mirjana; Medical Faculty Foca, University of East Sarajevo, Republic of Srpska, Bosnia and Herzegovina
dc.date2016-03-30
dc.date.accessioned2019-11-11T18:28:04Z
dc.date.available2019-11-11T18:28:04Z
dc.identifierhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/view/3931
dc.identifier.urihttps://revistaschilenas.uchile.cl/handle/2250/111419
dc.descriptionBackground: Benzodiazepines have a direct bronchodilatory effect. Methacholine is a non-selective muscarinic receptor agonist causing bronchoconstriction. Aim: To examine the effects of inhaled benzodiazepines, modulating bronchoconstriction induced by methacholine in patients with asthma. Patients and methods: Twelve patients with well controlled asthma were studied. On the first day, after determining the initial values of pulmonary function, a dose response curve was carried out with progressive doses of methacholine. After the last dose, when at least a 20% drop of the initial forced expiratory volume in the first second (FEV1) was achieved, vital capacity (VC) and FEV1 were measured at 7, 15 and 30 minutes after provocation. On the second day a diazepam aerosol was inhaled by the patients prior to the same protocol with methacholine. Results: In the first day of testing, methacholine inhalation (6 mg/mL) led to a significant drop in FEV1 from 2.98 to 1.69 L. On the second day of study, in the same patients, previous inhalation with diazepam reduced the changes of FEV1 after inhalation of methacholine. This parameter decreased from 2.48 to 2.21 L. Conclusions: Inhalation of benzodiazepines reduce bronchoconstriction after a methacholine challenge in patients with asthma.en-US
dc.descriptionBackground: Benzodiazepines have a direct bronchodilatory effect. Methacholine is a non-selective muscarinic receptor agonist causing bronchoconstriction. Aim: To examine the effects of inhaled benzodiazepines, modulating bronchoconstriction induced by methacholine in patients with asthma. Patients and methods: Twelve patients with well controlled asthma were studied. On the first day, after determining the initial values of pulmonary function, a dose response curve was carried out with progressive doses of methacholine. After the last dose, when at least a 20% drop of the initial forced expiratory volume in the first second (FEV1) was achieved, vital capacity (VC) and FEV1 were measured at 7, 15 and 30 minutes after provocation. On the second day a diazepam aerosol was inhaled by the patients prior to the same protocol with methacholine. Results: In the first day of testing, methacholine inhalation (6 mg/mL) led to a significant drop in FEV1 from 2.98 to 1.69 L. On the second day of study, in the same patients, previous inhalation with diazepam reduced the changes of FEV1 after inhalation of methacholine. This parameter decreased from 2.48 to 2.21 L. Conclusions: Inhalation of benzodiazepines reduce bronchoconstriction after a methacholine challenge in patients with asthma.es-ES
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dc.languageeng
dc.publisherRevista Médica de Chilees-ES
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dc.sourceRevista Médica de Chile; Vol. 144, núm. 4 (2016): ABRIL 2016es-ES
dc.source0034-9887
dc.subjectBenzodiazepines; Bronchoconstriction; Diazepam; Methacholine Chlorideen-US
dc.subjectBenzodiazepines; Bronchoconstriction; Diazepam; Methacholine Chloridees-ES
dc.titleREVERSION OF METHACHOLINE INDUCED BRONCHOCONSTRICTION WITH INHALED DIAZEPAM IN PATIENTS WITH ASTHMAen-US
dc.titleThe bronchodilatory effect of benzodiazepines on bronchoconstriction induced by methacholine in patients diagnosed with asthmaes-ES
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.typees-ES


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