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GLOBAL DNA METHYLATION AND HOMOCYSTEINE LEVELS ARE LOWER IN TYPE 1 DIABETES PATIENTS

La metilación global del ADN y los niveles de homocisteína en plasma se encuentran disminuidos en pacientes con Diabetes Mellitus tipo 1

dc.contributoren-US
dc.contributorProyecto Fondecyt 1130240es-ES
dc.creatorArroyo-Jousse, Viviana; Universidad de Chile
dc.creatorGarcía-Díaz, Diego F; Universidad de Chile
dc.creatorPérez-Bravo, Francisco; Universidad de Chile
dc.date2015-04-14
dc.date.accessioned2019-11-11T18:28:06Z
dc.date.available2019-11-11T18:28:06Z
dc.identifierhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/view/4054
dc.identifier.urihttps://revistaschilenas.uchile.cl/handle/2250/111447
dc.descriptionBackground: The worldwide rise in the incidence of Type 1 Diabetes (T1D), and the concordance rate between monozygotic twins (50%), indicate a strong effect of the environment as an underlying factor of this disease. This process can occur throughout epigenetic modifications of gene expression such as DNA methylation, in which several nutrients participate as cofactors. Aim: To determine DNA methylation status in T1D patients and if it is related to plasma levels of folates and homocysteine (Hcy). Material and methods: We obtained blood samples from 25 T1D patients aged 13.7 ± 5.9 years (11 males) and 25 healthy subjects aged 31.1 ± 7.8 years (16 males). DNA methylation was measured using a colorimetric kit in extracted DNA. Results are expressed as median (interquartile range). Results: Compared with healthy controls, T1D patients had lower global DNA methylation (0.85 (0.91) % and 1.25 (1.16) % respectively, pen-US
dc.descriptionBackground: The worldwide rise in the incidence of Type 1 Diabetes (T1D), and the concordance rate between monozygotic twins (50%), indicate a strong effect of the environment as an underlying factor of this disease. This process can occur throughout epigenetic modifications of gene expression such as DNA methylation, in which several nutrients participate as cofactors. Aim: To determine DNA methylation status in T1D patients and if it is related to plasma levels of folates and homocysteine (Hcy). Material and methods: We obtained blood samples from 25 T1D patients aged 13.7 ± 5.9 years (11 males) and 25 healthy subjects aged 31.1 ± 7.8 years (16 males). DNA methylation was measured using a colorimetric kit in extracted DNA. Results are expressed as median (interquartile range). Results: Compared with healthy controls, T1D patients had lower global DNA methylation (0.85 (0.91) % and 1.25 (1.16) % respectively, pes-ES
dc.formatapplication/pdf
dc.languagespa
dc.publisherRevista Médica de Chilees-ES
dc.relationhttp://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/view/4054/1138
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dc.sourceRevista Médica de Chile; Vol. 143, núm. 5 (2015): MAYO 2015es-ES
dc.source0034-9887
dc.subjectDNA methylation; Epigenetics; Folate; Type 1 Diabetesen-US
dc.subjectDNA methylation; Epigenetics; Folate; Type 1 Diabeteses-ES
dc.titleGLOBAL DNA METHYLATION AND HOMOCYSTEINE LEVELS ARE LOWER IN TYPE 1 DIABETES PATIENTSen-US
dc.titleLa metilación global del ADN y los niveles de homocisteína en plasma se encuentran disminuidos en pacientes con Diabetes Mellitus tipo 1es-ES
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.typees-ES


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