| dc.creator | Attia, Ali K. | |
| dc.creator | Frag, Eman Y. Z. | |
| dc.creator | Mohamed, Gehad G. | |
| dc.creator | Ahmed, Heba E. | |
| dc.date | 2015-12-10 | |
| dc.date.accessioned | 2019-11-13T15:11:20Z | |
| dc.date.available | 2019-11-13T15:11:20Z | |
| dc.identifier | http://www.jcchems.com/index.php/JCCHEMS/article/view/41 | |
| dc.identifier.uri | https://revistaschilenas.uchile.cl/handle/2250/112488 | |
| dc.description | A simple, precise, specific and accurate reversed phase HPLC (RP-HPLC) method has been developed for the determination of solifenacin succinate (SOLS), flavoxate HCl (FLXHC) and toltoridine tartarate (TOLT) in bulk and pharmaceutical dosage forms. The proposed RP-HPLC method was carried out using Xterra RP-18 column (5 μm practical size, 25 cm x 4.6 mm i.d.). The flow rate, the injection volume and the detection wavelength were 1.0 mL/min, 20 mL and 200 nm, respectively. The mobile phase consisted of 0.05 M pentane sulfonic acid sodium salt (SOLS: pH 3.0±0.05, FLXHC and TOLT: pH 5.5±0.05) and acetonitrile (50:50 v/v). The retention times for SOLS, FLXHC and TOLT drugs were found to be 4.1±0.1 min, 4.3±0.0 min and 5.8±0.1 min, respectively. The calibration was linear over the concentration range of 0.1-100 μg/mL. The mean recoveries for SOLS, FLXHC and TOLT drugs were about 99.80%, 100.43% and 100.00%, respectively. The method was validated according to the ICH guidelines with respect to specificity, linearity, accuracy, precision and robustness. | en-US |
| dc.format | application/pdf | |
| dc.language | eng | |
| dc.publisher | Sociedad Chilena de Química | en-US |
| dc.relation | http://www.jcchems.com/index.php/JCCHEMS/article/view/41/39 | |
| dc.rights | Copyright (c) 2016 Ali K. Attia, Eman Y. Z. Frag, Gehad G. Mohamed, Heba E. Ahmed | en-US |
| dc.rights | http://creativecommons.org/licenses/by-sa/4.0 | en-US |
| dc.source | Journal of the Chilean Chemical Society; Vol 61 No 1 (2016): Journal of the Chilean Chemical Society | en-US |
| dc.source | 0717-9707 | |
| dc.source | 0717-9324 | |
| dc.subject | Solifenacin succinate | en-US |
| dc.subject | Flavoxate HCl | en-US |
| dc.subject | Toltoridine tartarate | en-US |
| dc.subject | RP-HPLC | en-US |
| dc.title | LIQUID CHROMATOGRAPHIC DETERMINATION OF SOLIFENACIN SUCCINATE, FLAVOXATE HYDROCHLORIDE AND TOLTERODINE TARTRATE IN BULK DRUGS AND THEIR PHARMACEUTICAL DOSAGE FORMS | en-US |
| dc.type | info:eu-repo/semantics/article | |
| dc.type | info:eu-repo/semantics/publishedVersion | |
