SYNTHESIS AND ANTIMICROBIAL EVALUATION OF SOME NEW ASYMMETRICALLY SUBSTITUTED 4-ARYL- 2,6-DI(COUMARINYL) PYRIDINES
Chovatiya, Yogita L.
Kundaliya, Kaushik N.
Giri, Rakesh R.
Brahmbhatt, Dinker I.
In the present work the synthesis of various 4-aryl-2-(coumarin-3-yl)-6-(4-methyl-3-phenyl coumarin-6-yl)pyridines (6a-i) and 4-aryl-2-(coumarin-3-yl)- 6-(4-methyl-7-methoxy coumarin-8-yl)pyridines (7a-i) have been carried out by reacting 1-[2(H)-1-benzopyran-3-yl]-3-aryl-prop-2-en-1-ones (coumarinoyl chalcones) (3a-f) with appropriate coumarinoyl methyl pyridinium bromide salt 4 and 5 respectively. The target compounds were characterized by the IR, 1H-NMR, 13C-APT and mass spectral analysis. Preliminary examination of target compounds as antimicrobial agents has been carried out using Broth dilution method.