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TEMPERATURE EFFECT ON BINDING AFFINITY AND STOICHIOMETRY BETWEEN SOME STEROIDS AND HUMAN SERUM ALBUMIN

dc.creatorÖzdemir, Serkan
dc.creatorBiçer, Ender
dc.date2015-12-10
dc.date.accessioned2019-11-13T15:11:20Z
dc.date.available2019-11-13T15:11:20Z
dc.identifierhttp://www.jcchems.com/index.php/JCCHEMS/article/view/49
dc.identifier.urihttps://revistaschilenas.uchile.cl/handle/2250/112496
dc.descriptionThe temperature dependence of the interactions between some steroids (fusidic acid, ouabain and ethynodioldiacetate) and human serum albumin (HSA) at physiological pH (7.4) were studied systematically by square-wave voltammetry. Also, these interactions were proven by means of UV–Vis. absorption spectroscopy and FT-IR spectroscopy techniques. The interaction parameters (binding constants and stoichiometries) at temperature range of 297.5-312.5 K were determined from electrochemical data. It is worthy that the temperature has played a positive role on the interactions of fusidic acid with HSA; however it has negative effective on the interaction parameters of HSA with ouabain or ethynodioldiacetate.en-US
dc.formatapplication/pdf
dc.languageeng
dc.publisherSociedad Chilena de Químicaen-US
dc.relationhttp://www.jcchems.com/index.php/JCCHEMS/article/view/49/47
dc.rightsCopyright (c) 2016 Serkan Özdemir, Ender Biçeren-US
dc.rightshttp://creativecommons.org/licenses/by-sa/4.0en-US
dc.sourceJournal of the Chilean Chemical Society; Vol 61 No 1 (2016): Journal of the Chilean Chemical Societyen-US
dc.source0717-9707
dc.source0717-9324
dc.subjectSteroidsen-US
dc.subjectHuman serum albuminen-US
dc.subjectBinding affinityen-US
dc.subjectTemperature effecten-US
dc.subjectVoltammetryen-US
dc.titleTEMPERATURE EFFECT ON BINDING AFFINITY AND STOICHIOMETRY BETWEEN SOME STEROIDS AND HUMAN SERUM ALBUMINen-US
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion


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