IMPROVEMENT OF THE ANTIFUNGAL ACTIVITY AGAINST BOTRYTIS CINEREA OF SYRINGIC ACID, A PHENOLIC ACID FROM GRAPE POMACE

Mendoza, Leonora; Castro, Paulo; Melo, Ricardo; Campos, Ana María; Zúñiga, Gustavo; Guerrero, Juan; Cotoras, Milena

dc.creator	Mendoza, Leonora
dc.creator	Castro, Paulo
dc.creator	Melo, Ricardo
dc.creator	Campos, Ana María
dc.creator	Zúñiga, Gustavo
dc.creator	Guerrero, Juan
dc.creator	Cotoras, Milena
dc.date	2017-05-23
dc.date.accessioned	2019-11-13T15:11:22Z
dc.date.available	2019-11-13T15:11:22Z
dc.identifier	http://www.jcchems.com/index.php/JCCHEMS/article/view/69
dc.identifier.uri	https://revistaschilenas.uchile.cl/handle/2250/112509
dc.description	The aim of this study was to improve the antifungal activity against Botrytis cinerea of syringic acid by using the enzyme laccase to synthesize a heterodimeric compound by a coupling reaction with aniline. The synthesized heterodimer is a quinone-imine like compound (2,6-dimethoxy-4-(phenylimino)benzenone), which was characterized by using 1H and 13C NMR, IR, and mass spectrometry. The antifungal activity of the heterodimeric compound against B. cinerea was determined in vitro and showed a higher antifungal effect than the substrates (syringic acid and aniline), inhibiting the mycelial growth with an IC50 value of 0.14mM and delayed 2 hours the conidial germination. Also, using the fluorochrome calcofluor white, cell wall damage was observed when B. cinerea was incubated with the compound. This is the first report on antifungal activity of this type of compound against B. cinerea.	en-US
dc.format	application/pdf
dc.language	eng
dc.publisher	Sociedad Chilena de Química	en-US
dc.relation	http://www.jcchems.com/index.php/JCCHEMS/article/view/69/60
dc.rights	Copyright (c) 2017 Leonora Mendoza, Paulo Castro, Ricardo Melo, Ana María Campos, Gustavo Zúñiga, Juan Guerrero, Milena Cotoras	en-US
dc.rights	https://creativecommons.org/licenses/by-nc-sa/4.0	en-US
dc.source	Journal of the Chilean Chemical Society; Vol 61 No 3 (2016): Journal of the Chilean Chemical Society	en-US
dc.source	0717-9707
dc.source	0717-9324
dc.subject	Botrytis cinerea	en-US
dc.subject	Antifungal activity	en-US
dc.subject	Laccase	en-US
dc.subject	2	en-US
dc.subject	6-dimethoxy-4-(phenylimino)benzenone	en-US
dc.title	IMPROVEMENT OF THE ANTIFUNGAL ACTIVITY AGAINST BOTRYTIS CINEREA OF SYRINGIC ACID, A PHENOLIC ACID FROM GRAPE POMACE	en-US
dc.type	info:eu-repo/semantics/article
dc.type	info:eu-repo/semantics/publishedVersion

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