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dc.creatorMendoza, Leonora
dc.creatorCastro, Paulo
dc.creatorMelo, Ricardo
dc.creatorCampos, Ana María
dc.creatorZúñiga, Gustavo
dc.creatorGuerrero, Juan
dc.creatorCotoras, Milena
dc.date2017-05-23
dc.date.accessioned2019-11-13T15:11:22Z
dc.date.available2019-11-13T15:11:22Z
dc.identifierhttp://www.jcchems.com/index.php/JCCHEMS/article/view/69
dc.identifier.urihttps://revistaschilenas.uchile.cl/handle/2250/112509
dc.descriptionThe aim of this study was to improve the antifungal activity against Botrytis cinerea of syringic acid by using the enzyme laccase to synthesize a heterodimeric compound by a coupling reaction with aniline. The synthesized heterodimer is a quinone-imine like compound (2,6-dimethoxy-4-(phenylimino)benzenone), which was characterized by using 1H and 13C NMR, IR, and mass spectrometry. The antifungal activity of the heterodimeric compound against B. cinerea was determined in vitro and showed a higher antifungal effect than the substrates (syringic acid and aniline), inhibiting the mycelial growth with an IC50 value of 0.14mM and delayed 2 hours the conidial germination. Also, using the fluorochrome calcofluor white, cell wall damage was observed when B. cinerea was incubated with the compound. This is the first report on antifungal activity of this type of compound against B. cinerea.en-US
dc.formatapplication/pdf
dc.languageeng
dc.publisherSociedad Chilena de Químicaen-US
dc.relationhttp://www.jcchems.com/index.php/JCCHEMS/article/view/69/60
dc.rightsCopyright (c) 2017 Leonora Mendoza, Paulo Castro, Ricardo Melo, Ana María Campos, Gustavo Zúñiga, Juan Guerrero, Milena Cotorasen-US
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/4.0en-US
dc.sourceJournal of the Chilean Chemical Society; Vol 61 No 3 (2016): Journal of the Chilean Chemical Societyen-US
dc.source0717-9707
dc.source0717-9324
dc.subjectBotrytis cinereaen-US
dc.subjectAntifungal activityen-US
dc.subjectLaccaseen-US
dc.subject2en-US
dc.subject6-dimethoxy-4-(phenylimino)benzenoneen-US
dc.titleIMPROVEMENT OF THE ANTIFUNGAL ACTIVITY AGAINST BOTRYTIS CINEREA OF SYRINGIC ACID, A PHENOLIC ACID FROM GRAPE POMACEen-US
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion


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