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SOLID PHASE EXTRACTION AND LC-MS/MS METHOD FOR QUANTIFICATION OF VENLAFAXINE AND ITS ACTIVE METABOLITE O-DESMETHYL VENLAFAXINE IN RAT PLASMA

dc.creatorAhmad, Sarfaraz
dc.creatorSiddiqui, Masoom R.
dc.creatorAli, MD. S.
dc.creatorWabaidur, Saikh M.
dc.creatorAlam, MD. S.
dc.creatorAlam, Nawazish
dc.creatorAlothman, Zeid A.
dc.creatorKhan, Moonis Ali
dc.creatorKhan, Mohammad R.
dc.date2016-09-10
dc.date.accessioned2019-11-13T15:11:23Z
dc.date.available2019-11-13T15:11:23Z
dc.identifierhttp://www.jcchems.com/index.php/JCCHEMS/article/view/93
dc.identifier.urihttps://revistaschilenas.uchile.cl/handle/2250/112527
dc.descriptionA rapid, simple, sensitive LC-MS/MS method involving a least pretreatment process has been proposed for the quantitative assessment of venlafaxine (VEN) and O-desmethyl venlafaxine (ODV) using cetirizine as an internal standard. The method was validated over the range of 1.03 ng/mL to 453.50 ng/mL (venlafaxine) and 1.32 ng/mL to 585.21 ng/mL (O-desmethyl venlafaxine). The lowest limit of quantification for venlafaxine and O-desmethyl venlafaxine was found to be 1.03 ng/mL and 1.32 ng/mL, respectively. The solid phase extraction procedure provided reliable and reproducible recoveries of the drug as well as its active metabolite with no interference at their retention time. The recovery for all analyzed drugs was found to be in the range of 72.55% to 74.75%. The result indicates that the developed procedure could be considered suitable for carry out simultaneous preclinical pharmacokinetics studies for VEN and ODV. en-US
dc.formatapplication/pdf
dc.languageeng
dc.publisherSociedad Chilena de Químicaen-US
dc.relationhttp://www.jcchems.com/index.php/JCCHEMS/article/view/93/79
dc.rightsCopyright (c) 2017 Sarfaraz Ahmad, Masoom R. Siddiqui, MD. S. Ali, Saikh M. Wabaidur, MD. S. Alam, Nawazish Alam, Zeid A. Alothman, Moonis Ali Khan, Mohammad R. Khanen-US
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/4.0en-US
dc.sourceJournal of the Chilean Chemical Society; Vol 61 No 3 (2016): Journal of the Chilean Chemical Societyen-US
dc.source0717-9707
dc.source0717-9324
dc.subjectVenlafaxineen-US
dc.subjectO-desmethyl venlafaxineen-US
dc.subjectPharmacokineticsen-US
dc.subjectSolid phase extractionen-US
dc.subjectLC-MS/MSen-US
dc.titleSOLID PHASE EXTRACTION AND LC-MS/MS METHOD FOR QUANTIFICATION OF VENLAFAXINE AND ITS ACTIVE METABOLITE O-DESMETHYL VENLAFAXINE IN RAT PLASMAen-US
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion


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