| dc.creator | Ibacache, Juana Andrea | |
| dc.creator | Valderrama, Jaime A. | |
| dc.creator | Arancibia, Verónica | |
| dc.creator | Theoduloz, Cristina | |
| dc.creator | Muccioli, Giulio G. | |
| dc.creator | Benites, Julio | |
| dc.date | 2017-05-29 | |
| dc.date.accessioned | 2019-11-13T15:11:24Z | |
| dc.date.available | 2019-11-13T15:11:24Z | |
| dc.identifier | http://www.jcchems.com/index.php/JCCHEMS/article/view/108 | |
| dc.identifier.uri | https://revistaschilenas.uchile.cl/handle/2250/112541 | |
| dc.description | A variety of 6-bromine-containing 7-anilino-1-arylisoquinolinequinones 2a-g were synthesized to evaluate their half-wave potentials and in vitro antiproliferative activity on gastric and leukemia cancer cell lines. The new compounds displayed significant IC50 values in the range: 1.31 to 11.04 μM. The structure activity relationship analysis of the new series suggest that the antiproliferative activity is dependent, in part, on the push-pull electronic effects of the nitrogen and bromine substituents inserted into the redox fragment of the 1-arylisoquinolinequinone scaffold. Linear regression analysis provided satisfactory relationships between the log IC50 and ClogP values for the AGS gastric cancer cell line. | en-US |
| dc.format | application/pdf | |
| dc.language | eng | |
| dc.publisher | Sociedad Chilena de Química | en-US |
| dc.relation | http://www.jcchems.com/index.php/JCCHEMS/article/view/108/94 | |
| dc.rights | Copyright (c) 2017 Juana Andrea Ibacache, Jaime A. Valderrama, Verónica Arancibia, Cristina Theoduloz, Giulio G. Muccioli, Julio Benites | en-US |
| dc.rights | https://creativecommons.org/licenses/by-nc-sa/4.0 | en-US |
| dc.source | Journal of the Chilean Chemical Society; Vol 61 No 4 (2016): Journal of the Chilean Chemical Society | en-US |
| dc.source | 0717-9707 | |
| dc.source | 0717-9324 | |
| dc.subject | Isoquinolinequinones | en-US |
| dc.subject | Half-wave potentials | en-US |
| dc.subject | MTT assay | en-US |
| dc.subject | Antiproliferative activity | en-US |
| dc.title | ANTIPROLIFERATIVE ACTIVITY OF NEW 6-BROMINE DERIVATIVES OF 7-ANILINO-1- ARYLISOQUINOLINEQUINONES | en-US |
| dc.type | info:eu-repo/semantics/article | |
| dc.type | info:eu-repo/semantics/publishedVersion | |
