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  • Journal of the Chilean Chemical Society
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BENZAMIDE DERIVATIVES AS POTENTIAL CANDIDATES FOR ANTI-ALZHEIMER, ANTI-FATIGUE, ANTI-UREASE AND ANTI-OXIDANT ACTIVITY

Author
Taj, M. B.

Tirmizi, S. A.

Raheel, A.

Ali, H. B. M.

Qureshi, S.

Alshatir, H.

Full text
http://www.jcchems.com/index.php/JCCHEMS/article/view/144
Abstract
Benzamide derivatives were screened for their anti-alzheimer, anti-fatigue, anti-urease and anti-oxidant activity and their results were calculated in the form of %age inhibition and IC50 value. Compounds 3a and 3g exhibited the highest anti alzheimer activity. Group of mice’s treated by compounds 3f and 3g showed significantly longer swimming times than those of the treated with caffeine. The prominent urease inhibitory activity was shown by only one compound among seven benzamide derivatives. Controlled experiments suggest that benzamide derivatives (3a-3g) can be serve as the therapeutic agents.
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Discipline
Artes, Arquitectura y UrbanismoCiencias Agrarias, Forestales y VeterinariasCiencias Exactas y NaturalesCiencias SocialesDerechoEconomía y AdministraciónFilosofía y HumanidadesIngenieríaMedicinaMultidisciplinarias
Institutions
Universidad de ChileUniversidad Católica de ChileUniversidad de Santiago de ChileUniversidad de ConcepciónUniversidad Austral de ChileUniversidad Católica de ValparaísoUniversidad del Bio BioUniversidad de ValparaísoUniversidad Católica del Nortemore

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