| dc.creator | Rehman, Aziz Ur | |
| dc.creator | Ahtzaz, Samreen | |
| dc.creator | Abbasi, Muhammad Athar | |
| dc.creator | Siddiqui, Sabahat Zahra | |
| dc.creator | Rasool, Shahid | |
| dc.creator | Ahmad, Irshad | |
| dc.date | 2017-06-05 | |
| dc.date.accessioned | 2019-11-13T15:11:33Z | |
| dc.date.available | 2019-11-13T15:11:33Z | |
| dc.identifier | http://www.jcchems.com/index.php/JCCHEMS/article/view/151 | |
| dc.identifier.uri | https://revistaschilenas.uchile.cl/handle/2250/112576 | |
| dc.description | Owing to valuable biological activities of 1,3,4-oxadiazole, sulfamoyl and piperidine functionalities, some new 1-(4-{[(5-substituted-1,3,4-oxadiazol-2-yl) thio]methyl}benzene sulfonyl)-4-methylpiperidine (6a-o) derivatives have been introduced. The target molecules were synthesized from different aralkyl/aryl carboxylic acids, 1a-o, through a series of steps. First the compounds, 1a-o, were converted to heterocyclic 1,3,4-oxadiazole nucleophiles, 4a-o. Second an electrophile as 1-(4-bromomethylbenzenesulfonyl)-4-methylpiperidine (5) was synthesized from 4-methylpiperidine. Finally the target compounds, 6a-o, were prepared by reacting 4a-o with 5 in DMF and LiH. The final compounds were structurally elucidated by spectral data of IR, 1H-NMR and EI-MS. All the compounds were screened for their antibacterial evaluation and found to exhibit valuable results. | en-US |
| dc.format | application/pdf | |
| dc.language | eng | |
| dc.publisher | Sociedad Chilena de Química | en-US |
| dc.relation | http://www.jcchems.com/index.php/JCCHEMS/article/view/151/129 | |
| dc.rights | Copyright (c) 2017 Aziz Ur Rehman, Samreen Ahtzaz, Muhammad Athar Abbasi, Sabahat Zahra Siddiqui, Shahid Rasool, Irshad Ahmad | en-US |
| dc.rights | https://creativecommons.org/licenses/by-nc-sa/4.0 | en-US |
| dc.source | Journal of the Chilean Chemical Society; Vol 62 No 1 (2017): Journal of the Chilean Chemical Society | en-US |
| dc.source | 0717-9707 | |
| dc.source | 0717-9324 | |
| dc.subject | 1 | en-US |
| dc.subject | 3 | en-US |
| dc.subject | 4-oxadiazole | en-US |
| dc.subject | 4-methylpiperidine | en-US |
| dc.subject | Antibacterial activity | en-US |
| dc.subject | Sulfonamide | en-US |
| dc.subject | 1H-NMR | en-US |
| dc.subject | EI-MS | en-US |
| dc.title | SYNTHESIS, SPECTRAL ANALYSIS AND ANTIBACTERIAL EVALUATION OF 5-SUBSTITUTED-1,3,4- OXADIAZOL-2-YL 4-(4-METHYLPIPERIDIN-1-YLSULFONYL)BENZYL SULFIDES | en-US |
| dc.type | info:eu-repo/semantics/article | |
| dc.type | info:eu-repo/semantics/publishedVersion | |
