CAPTISOL® AS CHIRAL SELECTOR IN CAPILLARY ELECTROPHORESIS OF NON-ACIDIC DRUGS

Budău, Monica; Hancu, Gabriel; István Szabó, Zoltán; Kelemen, Hajnal; Rusu, Aura; Muntean, Daniela Lucia; Gabriela Cârje, Anca

dc.creator	Budău, Monica
dc.creator	Hancu, Gabriel
dc.creator	István Szabó, Zoltán
dc.creator	Kelemen, Hajnal
dc.creator	Rusu, Aura
dc.creator	Muntean, Daniela Lucia
dc.creator	Gabriela Cârje, Anca
dc.date	2017-09-02
dc.date.accessioned	2019-11-13T15:11:36Z
dc.date.available	2019-11-13T15:11:36Z
dc.identifier	http://www.jcchems.com/index.php/JCCHEMS/article/view/311
dc.identifier.uri	https://revistaschilenas.uchile.cl/handle/2250/112614
dc.description	Enantioseparation of nine extensively used chiral pharmaceutical substances from different pharmacological classes and with different structural characteristics has been investigated by capillary zone electrophoresis using Captisol® (sulfobuthylether-β-cyclodextrin sodium salt) as chiral selector. The influence on the chiral separation of several parameters including pH and concentration of the background electrolyte, chiral selector concentration, applied voltage, system temperature and injection parameters were studied and optimized in order to obtain increased chiral resolution and shorten analysis time. The results were compared with those obtained with native and derivatized neutral cyclodextrins (β-cyclodextrin and hydroxypropryl-β-cyclodextrin). All model molecules were resolved using Captisol® as chiral additive and optimized electrophoretic conditions, proving the efficiency of this anionic derivative of β- cyclodextrin as chiral selector in capillary electrophoresis.	en-US
dc.format	application/pdf
dc.language	eng
dc.publisher	Sociedad Chilena de Química	en-US
dc.relation	http://www.jcchems.com/index.php/JCCHEMS/article/view/311/168
dc.rights	Copyright (c) 2017 Journal of the Chilean Chemical Society	en-US
dc.rights	https://creativecommons.org/licenses/by-nc-sa/4.0	en-US
dc.source	Journal of the Chilean Chemical Society; Vol 62 No 3 (2017): Journal of the Chilean Chemical Society	en-US
dc.source	0717-9707
dc.source	0717-9324
dc.subject	chiral separation	en-US
dc.subject	Captisol®	en-US
dc.subject	capillary electrophoresis	en-US
dc.subject	cyclodextrines	en-US
dc.subject	pharmaceutical analysis	en-US
dc.title	CAPTISOL® AS CHIRAL SELECTOR IN CAPILLARY ELECTROPHORESIS OF NON-ACIDIC DRUGS	en-US
dc.type	info:eu-repo/semantics/article
dc.type	info:eu-repo/semantics/publishedVersion

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