SYNTHESIS OF BENZOXAZEPINE DERIVATIVES FROM PYRAZOLE-CHALCONE VIA A SIMPLE AND CONVENIENT PROTOCOL USING BASIC ALUMINA AS SOLID SUPPORT

Ashok, D.; Radhika, G.; Ananda Rao, Boddu; Sarasija, M.; Jayashree, A.; Sadanandam, P.

dc.creator	Ashok, D.
dc.creator	Radhika, G.
dc.creator	Ananda Rao, Boddu
dc.creator	Sarasija, M.
dc.creator	Jayashree, A.
dc.creator	Sadanandam, P.
dc.date	2018-06-25
dc.date.accessioned	2019-11-13T15:11:47Z
dc.date.available	2019-11-13T15:11:47Z
dc.identifier	http://www.jcchems.com/index.php/JCCHEMS/article/view/682
dc.identifier.uri	https://revistaschilenas.uchile.cl/handle/2250/112686
dc.description	In the present study a series of novel benzoxazepine (5a-h) derivatives were synthesized by the thermal cyclization reaction of various pyrazole-chalcones (3a-h) with 2-aminophenol, by conventional heating and microwave irradiation (180 W) in solvent-free conditions in short reaction times (9–12 min), giving high yields of products (80–88%). The homogeneity of all the newly synthesized compounds has been checked by TLC. Their IR, NMR, ESI-mass spectral data and elemental analysis are in accord with the assigned structure. The title compounds were evaluated for their antibacterial activity against Gram-positive bacteria Staphylococcus aureus, Bacillus subtilis, and Gram-negative bacteria Pseudomonas aeruginosa, Escherichia coli. Compounds 3c, 3h, 5b, 5c, 5g and 5h were found to show good antibacterial activity when compared with that of standard drug Ampicillin. Furthermore, the same library of compounds were evaluated for antifungal activity against Aspergillus nigerzeae, Penicillium italicum and Fusarium oxysporum using Grieseofulvin as standard drug. The results of the above studies show that the compounds 3b, 3c, 3e, 3h, 5a, 5c, 5g and 5h showed good antifungal activity against all the tested organisms.	en-US
dc.format	application/pdf
dc.language	eng
dc.publisher	Sociedad Chilena de Química	en-US
dc.relation	http://www.jcchems.com/index.php/JCCHEMS/article/view/682/240
dc.rights	Copyright (c) 2018 Journal of the Chilean Chemical Society	en-US
dc.rights	https://creativecommons.org/licenses/by-nc-sa/4.0	en-US
dc.source	Journal of the Chilean Chemical Society; Vol 63 No 2 (2018): Journal of the Chilean Chemical Society	en-US
dc.source	0717-9707
dc.source	0717-9324
dc.subject	Pyrazole	en-US
dc.subject	Chalcone	en-US
dc.subject	benzoxazepine	en-US
dc.subject	microwave irradiation	en-US
dc.subject	basic alumina	en-US
dc.title	SYNTHESIS OF BENZOXAZEPINE DERIVATIVES FROM PYRAZOLE-CHALCONE VIA A SIMPLE AND CONVENIENT PROTOCOL USING BASIC ALUMINA AS SOLID SUPPORT	en-US
dc.type	info:eu-repo/semantics/article
dc.type	info:eu-repo/semantics/publishedVersion

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