dc.creator | Mi, Ya-xuan | |
dc.creator | Wang, Shuang | |
dc.creator | Xu, Xue-Xue | |
dc.creator | Zhao, Hua-Qian | |
dc.creator | Zheng, Ze-Bao | |
dc.creator | Zhao, Xiao-Long | |
dc.date | 2019-03-27 | |
dc.date.accessioned | 2019-11-13T15:11:54Z | |
dc.date.available | 2019-11-13T15:11:54Z | |
dc.identifier | http://www.jcchems.com/index.php/JCCHEMS/article/view/1051 | |
dc.identifier.uri | https://revistaschilenas.uchile.cl/handle/2250/112750 | |
dc.description | A dinuclear ruthenium complex [Ru2(bpy)4(bip-phenol)](ClO4)4 {bpy = 2,2′-bipyridine, bip-phenol = 2,4-bis(1H-imidazo[4,5-f][1,10]phenanthrolin-2-yl) phenol} has been synthesized and characterized. The calf thymus (ct) DNA binding properties of the complex are investigated by means of DNA viscosity and optical spectroscopic techniques of UV-visible absorption and emission spectral titrations, steady-state emission quenching with ferrocyanide, ethidium bromide competitive binding, DNA thermal denaturation and reverse salt effect, together with molecular simulation technology. The results suggest that the complex is a promising DNA groove binder with a large DNA binding constant on 106 M−1 order of magnitude. The fluorescence of the complex manifests by 6.3-fold upon binding saturately to DNA. The complex is also demonstrated to be an efficient photocleaver of pBR 322 DNA. | en-US |
dc.format | application/pdf | |
dc.language | eng | |
dc.publisher | Sociedad Chilena de Química | en-US |
dc.relation | http://www.jcchems.com/index.php/JCCHEMS/article/view/1051/305 | |
dc.rights | Copyright (c) 2019 Journal of the Chilean Chemical Society | en-US |
dc.rights | https://creativecommons.org/licenses/by-nc-sa/4.0 | en-US |
dc.source | Journal of the Chilean Chemical Society; Vol 64 No 1 (2019): Journal of the Chilean Chemical Society | en-US |
dc.source | 0717-9707 | |
dc.source | 0717-9324 | |
dc.subject | Ruthenium(II) complex | en-US |
dc.subject | Calf thymus DNA | en-US |
dc.subject | Groove mode | en-US |
dc.title | A PROMISING DNA GROOVE BINDER AND PHOTOCLEAVER BASED ON A DINUCLEAR RUTHENIUM(II) COMPLEX | en-US |
dc.type | info:eu-repo/semantics/article | |
dc.type | info:eu-repo/semantics/publishedVersion | |