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dc.creatorMi, Ya-xuan
dc.creatorWang, Shuang
dc.creatorXu, Xue-Xue
dc.creatorZhao, Hua-Qian
dc.creatorZheng, Ze-Bao
dc.creatorZhao, Xiao-Long
dc.date2019-03-27
dc.date.accessioned2019-11-13T15:11:54Z
dc.date.available2019-11-13T15:11:54Z
dc.identifierhttp://www.jcchems.com/index.php/JCCHEMS/article/view/1051
dc.identifier.urihttps://revistaschilenas.uchile.cl/handle/2250/112750
dc.descriptionA dinuclear ruthenium complex [Ru2(bpy)4(bip-phenol)](ClO4)4 {bpy = 2,2′-bipyridine, bip-phenol = 2,4-bis(1H-imidazo[4,5-f][1,10]phenanthrolin-2-yl) phenol} has been synthesized and characterized. The calf thymus (ct) DNA binding properties of the complex are investigated by means of DNA viscosity and optical spectroscopic techniques of UV-visible absorption and emission spectral titrations, steady-state emission quenching with ferrocyanide, ethidium bromide competitive binding, DNA thermal denaturation and reverse salt effect, together with molecular simulation technology. The results suggest that the complex is a promising DNA groove binder with a large DNA binding constant on 106 M−1 order of magnitude. The fluorescence of the complex manifests by 6.3-fold upon binding saturately to DNA. The complex is also demonstrated to be an efficient photocleaver of pBR 322 DNA.en-US
dc.formatapplication/pdf
dc.languageeng
dc.publisherSociedad Chilena de Químicaen-US
dc.relationhttp://www.jcchems.com/index.php/JCCHEMS/article/view/1051/305
dc.rightsCopyright (c) 2019 Journal of the Chilean Chemical Societyen-US
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/4.0en-US
dc.sourceJournal of the Chilean Chemical Society; Vol 64 No 1 (2019): Journal of the Chilean Chemical Societyen-US
dc.source0717-9707
dc.source0717-9324
dc.subjectRuthenium(II) complexen-US
dc.subjectCalf thymus DNAen-US
dc.subjectGroove modeen-US
dc.titleA PROMISING DNA GROOVE BINDER AND PHOTOCLEAVER BASED ON A DINUCLEAR RUTHENIUM(II) COMPLEXen-US
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion


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