Show simple item record

ANTIMICROBIAL ACTIVITY AND IN SILICO STUDY OF METHYLIMIDAZOLIUM-FURANCHALCONE HYBRIDS AND 1-ALKYL-3-METHYLIMIDAZOLIUM SALTS

dc.creatorAraque, Pedronel
dc.creatorHerrera, Angie
dc.creatorMontaño, Diego
dc.creatorYepes, Andres
dc.creatorGarcía, Elisa
dc.creatorSepúlveda, Jovany
dc.creatorTorijano, Sandra
dc.creatorCardona-G., Wilson
dc.date2019-10-30
dc.date.accessioned2019-11-13T15:11:55Z
dc.date.available2019-11-13T15:11:55Z
dc.identifierhttp://www.jcchems.com/index.php/JCCHEMS/article/view/1318
dc.identifier.urihttps://revistaschilenas.uchile.cl/handle/2250/112778
dc.descriptionA set of methylimidazolium-furanchalcone hybrids and 1-alkyl-3-methylimidazolium salts were tested in order to find their antimicrobial activity against five grampositive bacteria, two gram negative bacteria and three fungi. In the series of 1-alkyl-3-methylimidazolium salts, compounds 4 and 7 were the most active compoundsagainst S. mutans and F. oxysporum, respectively (MIC value of 3.0 and 6.7 mM, respectively). In addition, among the hybrid molecules, compound 10 exhibited thehighest activity against F. solani (MIC50 = 14.3 mM) followed by hybrid 11 (MIC50 = 14.5 mM), which was also the most active against S. aureus, S. mutans (MIC50= 14.6, 18.7 mM, respectively). The activity of these hybrids was even better with regard to the lead compounds (furanchalcone, methylimidazole or the mixture). Inthe structure-activity relationship there was observed higher bioactivity when the alkyl linker had eigth carbon atoms. This was then supported by the in silico studywhich displayed a strong relationship between the length of the alkyl chain on N and the biological activity. The results highlight the importance of these derivatives(1-alkyl-3-methylimidazolium salts) and hybrids (methylimidazolium-furanchalcone) as potential antimicrobial agents.en-US
dc.formatapplication/pdf
dc.languageeng
dc.publisherSociedad Chilena de Químicaen-US
dc.relationhttp://www.jcchems.com/index.php/JCCHEMS/article/view/1318/333
dc.sourceJournal of the Chilean Chemical Society; Vol 64 No 3 (2019): Journal of the Chilean Chemical Society; 4547-4552en-US
dc.source0717-9707
dc.source0717-9324
dc.subjectAntibacterialen-US
dc.subjectantifungalen-US
dc.subjectionic liquiden-US
dc.subjectin silico studyen-US
dc.subjecthybrid moleculesen-US
dc.titleANTIMICROBIAL ACTIVITY AND IN SILICO STUDY OF METHYLIMIDAZOLIUM-FURANCHALCONE HYBRIDS AND 1-ALKYL-3-METHYLIMIDAZOLIUM SALTSen-US
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion


This item appears in the following Collection(s)

Show simple item record