Isradipine (ISRA) is a calcium channel blocking agent and a drug of the dihydropyridine (DHP) class. It is utilized for the treatment of hypertension and congestivecardiac failure (CHF). It selectively binds with the calcium channel receptor with high compatibility and averts calcium alteration into cardiac and arterial smoothmuscle cells. ISRA employed to cure deliberate hypertension, used alone or in combination with thiazide diuretics. The present review article represents thecompilation and discussion of analytical methods published in the literature for estimation of ISRA in pharmaceutical samples and biological matrices consisting ofTLC/ densitometry, HPLC, UV-Visible method, Spectrofluorometry, Capillary Electrophoresis (CE), Polarography, Voltammetry and hyphenated techniques suchas LC-MS; LC-MS-MS, GC-MS, etc.