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dc.creatorSantolaya de P,María Elena
dc.date1998-07-01
dc.date.accessioned2019-11-14T12:50:42Z
dc.date.available2019-11-14T12:50:42Z
dc.identifierhttps://scielo.conicyt.cl/scielo.php?script=sci_arttext&pid=S0034-98871998000700014
dc.identifier.urihttps://revistaschilenas.uchile.cl/handle/2250/114291
dc.descriptionThe role of superantigens in infectious diseases Exogenous antigens are presented to T lymphocytes through a mechanism that ensures a high recognition specificity. On the other hand, recently described superantigens are particles that do not follow the processing or presentation route and do not bind to a specific region of T lymphocyte receptors, as conventional antigens. These particles bind to a large number of T lymphocytes, generating a disproportionate and unspecific immune response. Two types of superantigens have been described. Endogenous superantigens, that are transported in the host genoma, and that are involved in clonal depletion and immunological tolerance phenomena. Exogenous superantigens, mostly bacterial toxins, are involved in several diseases. There is evidence that these antigens participate in diseases such as Kawasaki disease, toxic shock caused by Staphylococcus aureus, rheumatoid arthritis, HIV infection and Streptococcus pyogenes infections
dc.formattext/html
dc.languagees
dc.publisherSociedad Médica de Santiago
dc.relation10.4067/S0034-98871998000700014
dc.rightsinfo:eu-repo/semantics/openAccess
dc.sourceRevista médica de Chile v.126 n.7 1998
dc.subjectSuperantigens
dc.subjectReceptors, antigen, T-cell, alpha-beta
dc.subjectInfections diseases
dc.subjectBacterial toxins
dc.titleSuperantígenos y su rol en enfermedades infecciosas


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