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dc.creatorRoa S,Juan C
dc.creatorRoa E,Iván
dc.creatorAraya O,Juan C
dc.creatorVillaseca H,Miguel A
dc.creatorMelo A,Angélica
dc.creatorBurgos S,Luis
dc.date2000-11-01
dc.date.accessioned2019-11-14T12:51:39Z
dc.date.available2019-11-14T12:51:39Z
dc.identifierhttps://scielo.conicyt.cl/scielo.php?script=sci_arttext&pid=S0034-98872000001100013
dc.identifier.urihttps://revistaschilenas.uchile.cl/handle/2250/114918
dc.descriptionMalignant diseases of the digestive tract cause more than 50% of deaths due to cancer in Chile. There is a high incidence of gastric and gallbladder cancer and an increasing frequency of colorectal cancer. P53 tumor suppressor gene has a great importance in carcinogenesis and its alterations are specially important in digestive tract tumors such as colorectal cancer. There is contradictory evidence about the frequency of p53 gene or protein alterations or their biological significance. There is little information about p53 in Chile and it is mostly limited to immunohistochemical studies. This revision analyzes the frequency of p53 alterations in digestive tract tumors in Chile, using immunohistochemical and molecular biology methods. A special emphasis is given to the prognostic importance of this gene (Rev Méd Chile 2000; 128: 1269-78)
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dc.languagees
dc.publisherSociedad Médica de Santiago
dc.relation10.4067/S0034-98872000001100013
dc.rightsinfo:eu-repo/semantics/openAccess
dc.sourceRevista médica de Chile v.128 n.11 2000
dc.subjectGenes, p53
dc.subjectGenetic markers
dc.subjectGenetic predisposition to disease
dc.subjectDigestive system neoplasm
dc.titleGen supresor de tumores p53 en neoplasias digestivas


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