| dc.creator | ALDERETE,JOEL B. | |
| dc.date | 2000-09-01 | |
| dc.date.accessioned | 2019-11-14T12:51:46Z | |
| dc.date.available | 2019-11-14T12:51:46Z | |
| dc.identifier | https://scielo.conicyt.cl/scielo.php?script=sci_arttext&pid=S0366-16442000000300004 | |
| dc.identifier.uri | https://revistaschilenas.uchile.cl/handle/2250/114986 | |
| dc.description | ABSTRACT The syn-anti conformational equilibrium for a series of nine cyclic nucleotides was studied at semiempirical AM1 level. The AM1 results indicate that for guanosine cyclic 3',5'-monophosphate and their derivatives substituted at 8-position, the syn-conformers are more stable than the anti ones. For purine derivatives without an amino group at position 2, which participate in a hydrogen bonding with the axial oxygen of the phosphate group, the anti conformation is preferred.	 	The AM1 results suggest that syn-anti equilibruim is a dominant factor for the binding of cyclic nucleotides to cyclic phosphodiesterases. Reinterpretation of experimental results for the competitive inhibition of c-GMP-stimulated phosphodiesterase was performed. | |
| dc.format | text/html | |
| dc.language | en | |
| dc.publisher | Sociedad Chilena de Química | |
| dc.relation | 10.4067/S0366-16442000000300004 | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.source | Boletín de la Sociedad Chilena de Química v.45 n.3 2000 | |
| dc.subject | AM1 | |
| dc.subject | cyclic nucleotides | |
| dc.subject | syn-anti equilibrium | |
| dc.subject | phosphodiesterases | |
| dc.title | The Syn-Anti Equilibrium of Guanosine Cyclic 3',5'- Monophosphate and 8-Sustituted Derivatives: A Theoretical Study | |
