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dc.creatorAVALOS,ANA MARIA
dc.creatorLABRA,CECILIA V.
dc.creatorQUEST,ANDREW F.G.
dc.creatorLEYTON,LISSETTE
dc.date2002-01-01
dc.date.accessioned2019-11-14T12:54:28Z
dc.date.available2019-11-14T12:54:28Z
dc.identifierhttps://scielo.conicyt.cl/scielo.php?script=sci_arttext&pid=S0716-97602002000200015
dc.identifier.urihttps://revistaschilenas.uchile.cl/handle/2250/116594
dc.descriptionThy-1 is an abundant neuronal glycoprotein in mammals. Despite such prevalence, Thy-1 function remains largely obscure in the absence of a defined ligand. Recently described evidence that Thy-1 interacts with ß3 integrin on astrocytes will be discussed. Thy-1 binding to ß3 integrin triggers tyrosine phosphorylation of focal adhesion proteins in astrocytes, thereby promoting focal adhesion formation, cell attachment and spreading. Thy-1 has been reported to modulate neurite outgrowth by triggering a cellular response in neurons. However, our data indicate that Thy-1 can also initiate signaling events that promote adhesion of adjacent astrocytes to the underlying surface. Preliminary results suggest that morphological changes observed in the actin cytoskeleton of astrocytes as a consequence of Thy-1 binding is mediated by small GTPases from the Rho family. Our findings argue that Thy-1 functions in a bimodal fashion, as a receptor on neuronal cells and as a ligand for ß3 integrin receptor on astrocytes. Since Thy-1 is implicated in the inhibition of neurite outgrowth, signaling events in astrocytes are likely to play an important role in this process
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dc.languageen
dc.publisherSociedad de Biología de Chile
dc.relation10.4067/S0716-97602002000200015
dc.rightsinfo:eu-repo/semantics/openAccess
dc.sourceBiological Research v.35 n.2 2002
dc.subjectThy-1 ligand/integrins
dc.subjectGPI-anchored proteins
dc.subjectstrocytes
dc.subjectfocal adhesion
dc.titleSignaling triggered by Thy-1 interaction with ß3 integrin on astrocytes is an essential step towards unraveling neuronal Thy-1 function


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