| dc.creator | Prat M.,Hernán | |
| dc.date | 2000-05-01 | |
| dc.date.accessioned | 2019-11-14T12:58:05Z | |
| dc.date.available | 2019-11-14T12:58:05Z | |
| dc.identifier | https://scielo.conicyt.cl/scielo.php?script=sci_arttext&pid=S0034-98872000000500004 | |
| dc.identifier.uri | https://revistaschilenas.uchile.cl/handle/2250/118680 | |
| dc.description | Background: Valsartan is an angiotensin AT1 receptor antagonist. Clinical studies have shown that this is an effective and well tolerated drug. Aim: To compare valsartan with other commonly used antihypertensives in a National multicentric study. Material and methods: Between 1997 and 1998, a pharmacological surveillance of patients with mild or moderate hypertension, coming from different regions of the country, was carried out. Patients were followed during 8 weeks. In the group treated with valsartan, the initial dose was 80 mg/day. After four weeks of therapy, and according to patient's response the dose of valsartan or of the other antihypertensives was modified. Results: Five hundred ninety three patients, aged 59 years old as a mean, were included in the study. Of these 434 (265 female) received valsartan and 159 (101 female) other antihypertensive drugs. Fifteen percent of patients treated with valsartan and 25% of patients with other medications required a dose change at four weeks, due to lack of response (p < 0.01). At week eight, 1.5% of patients with valsartan and 17.4% of patients with other medications reported adverse effects such as cough, headache, edema or flushing (p < 0.01). Conclusions: In this Chilean observational multicentric study, valsartan proved to be more effective and to cause less adverse effects than commonly used medications in hypertensive patients. (Rev Méd Chile 2000; 128: 475-82) | |
| dc.format | text/html | |
| dc.language | es | |
| dc.publisher | Sociedad Médica de Santiago | |
| dc.relation | 10.4067/S0034-98872000000500004 | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.source | Revista médica de Chile v.128 n.5 2000 | |
| dc.subject | Angiotensins | |
| dc.subject | Hypertension | |
| dc.subject | Valsartan | |
| dc.title | Efecto antihipertensivo del valsartán: Estudio multicéntrico nacional | |
