RENAL MORPHOMETRY OF FETUSES RATS TREATED WITH CADMIUM
Roman,T. R. N.
de Lima,E. G.
Cadmium is a heavy metal which is found in the soil, air and food. It is present in everyday life and currently it is being implicated as a toxic, teratogenic and carcinogenic agent. It causes lesions to several organs of humans and animals alike. This work aims to investigate the toxic effects on fetuses of dams exposed to cadmium chloride treatment. Ten pregnant rats were divided into two groups. Five rats, the study group, received an intraperitoneal administration of cadmium chloride at 5 mg/Kg body weight on the 10th day of pregnancy and the other five, the study group, received a solution of 0.85% sodium chloride at the same dose and at the same application site. The fetuses together with the placentas and umbilical cords were collected on the 20th day of pregnancy. The administration of cadmium chloride caused a significant reduction in the sizes of both the fetuses and the placenta. The lengths of the umbilical cords were also shorter in animals of the study group when compared with the control group. This study also evaluated the morphological alterations caused in the proximal and distal convoluted renal tubules and collectors as well as the renal glomerular cells. Morphometry evidenced significant alterations in the proximal tubules and the glomerular cells and to a lesser degree in the distal tubules. The brush-border membrane cells were seen to be very sensitive and displayed some alterations. The glomeruli presented with edema and the Bowman's capsules were also affected